Progesterone Attenuates Brain Inflammatory Response and Inflammation-Induced Increase in Immature Myeloid Cells in a Mouse Model

Progesterone has been shown to regulate immunity during pregnancy, and progesterone administration may reduce inflammation-induced preterm labor. We sought to determine the maternal brain immune response to LPS-induced inflammation in pregnant and non-pregnant mice and whether additional progesteron...

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Veröffentlicht in:	Inflammation 2021-06, Vol.44 (3), p.956-964
Hauptverfasser:	Gutzeit, Ola, Segal, Linoy, Korin, Ben, Iluz, Roee, Khatib, Nizar, Dabbah-Assadi, Fadwa, Ginsberg, Yuval, Fainaru, Ofer, Ross, Michael G., Weiner, Zeev, Beloosesky, Ron
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Biomedical and Life Sciences Biomedicine Brain Brain - drug effects Brain - immunology Brain - metabolism Disease Models, Animal Female Gestational Age Immune response Immunology Inflammation Inflammation - chemically induced Inflammation - immunology Inflammation - metabolism Inflammation - prevention & control Inflammation Mediators - metabolism Interleukin 6 Interleukin-6 - metabolism Internal Medicine Lipopolysaccharides Mice Mice, Inbred ICR Myeloid cells Myeloid Cells - drug effects Myeloid Cells - immunology Myeloid Cells - metabolism Neuroimmunomodulation - drug effects NF-kappa B - metabolism NF-κB protein Nitric Oxide Synthase Type I - metabolism Original Original Article Pathology Pharmacology/Toxicology Phenotypes Pregnancy Progesterone Progesterone - pharmacology Rheumatology Supplements Vagina
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