Adult neural stem cells have latent inflammatory potential that is kept suppressed by Tcf4 to facilitate adult neurogenesis
Inflammation is known to adversely affect adult neurogenesis, wherein the source of inflammation is largely thought to be extraneous to the neurogenic niche. Here, we demonstrate that the adult hippocampal neural progenitors harbor an inflammatory potential that is proactively suppressed by transcri...
Gespeichert in:
| Veröffentlicht in: | Science advances 2021-05, Vol.7 (21) |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 21 |
| container_start_page | |
| container_title | Science advances |
| container_volume | 7 |
| creator | Shariq, Mohammad Sahasrabuddhe, Vinaya Krishna, Sreevatsan Radha, Swathi Nruthyathi Bellampalli, Ravishankara Dwivedi, Anukriti Cheramangalam, Rajit Reizis, Boris Hébert, Jean Ghosh, Hiyaa S |
| description | Inflammation is known to adversely affect adult neurogenesis, wherein the source of inflammation is largely thought to be extraneous to the neurogenic niche. Here, we demonstrate that the adult hippocampal neural progenitors harbor an inflammatory potential that is proactively suppressed by transcription factor 4 (
). Deletion of
in hippocampal
-expressing progenitors causes loss of proliferative capacity and acquisition of myeloid inflammatory properties. This transformation abolishes their differentiation potential and causes production of detrimental factors that adversely affect niche cells, causing inflammation in the dentate gyrus. Thus, on one hand,
deletion causes abrogation of proliferative progenitors leading to reduction of adult neurogenesis, while on the other, their accompanying inflammatory transformation inflicts inflammation in the niche. Taken together, we provide the first evidence for a latent inflammatory potential of adult hippocampal neural progenitors and identify
as a critical regulator that facilitates adult neurogenesis via proactive suppression of this detrimental potential. |
| doi_str_mv | 10.1126/sciadv.abf5606 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8139598</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2531242005</sourcerecordid><originalsourceid>FETCH-LOGICAL-c390t-362170005f19da3b43b86ff82a8c041ebe6983ea7c2595b8b505708b5db1fa473</originalsourceid><addsrcrecordid>eNpVUU1rGzEQFaElCW6uPRYde7Gjz_24FEJok0Kgl_QsRtpRrHZ3tV1pDaZ_PjJ2TXqaYebNmzfzCPnI2YZzUd0mF6DbbcB6XbHqglwLWeu10Kp59ya_Ijcp_WKMcVVVmreX5EoqJlir1TX5e9ctfaYjLjP0NGUcqMO-T3QLO6Q9ZBwzDaPvYRggx3lPp3iohYLOWyi9RH_jlGlapmnGlLCjdk-fnVc0R-rBhT7kQkPhvCi-4IgppA_kvYc-4c0prsjPb1-f7x_XTz8evt_fPa2dbFley0rwusjXnrcdSKukbSrvGwGNY4qjxaptJELthG61baxmumYldJZ7ULVckS9H3mmxA3auyC_HmmkOA8x7EyGY_ztj2JqXuDMNl60u3Cvy-UQwxz8LpmyGkA5vghHjkozQkgslisQC3Ryhbo4pzejPazgzB9PM0TRzMq0MfHor7gz_Z5F8BUMCl_U</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2531242005</pqid></control><display><type>article</type><title>Adult neural stem cells have latent inflammatory potential that is kept suppressed by Tcf4 to facilitate adult neurogenesis</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Shariq, Mohammad ; Sahasrabuddhe, Vinaya ; Krishna, Sreevatsan ; Radha, Swathi ; Nruthyathi ; Bellampalli, Ravishankara ; Dwivedi, Anukriti ; Cheramangalam, Rajit ; Reizis, Boris ; Hébert, Jean ; Ghosh, Hiyaa S</creator><creatorcontrib>Shariq, Mohammad ; Sahasrabuddhe, Vinaya ; Krishna, Sreevatsan ; Radha, Swathi ; Nruthyathi ; Bellampalli, Ravishankara ; Dwivedi, Anukriti ; Cheramangalam, Rajit ; Reizis, Boris ; Hébert, Jean ; Ghosh, Hiyaa S</creatorcontrib><description>Inflammation is known to adversely affect adult neurogenesis, wherein the source of inflammation is largely thought to be extraneous to the neurogenic niche. Here, we demonstrate that the adult hippocampal neural progenitors harbor an inflammatory potential that is proactively suppressed by transcription factor 4 (
). Deletion of
in hippocampal
-expressing progenitors causes loss of proliferative capacity and acquisition of myeloid inflammatory properties. This transformation abolishes their differentiation potential and causes production of detrimental factors that adversely affect niche cells, causing inflammation in the dentate gyrus. Thus, on one hand,
deletion causes abrogation of proliferative progenitors leading to reduction of adult neurogenesis, while on the other, their accompanying inflammatory transformation inflicts inflammation in the niche. Taken together, we provide the first evidence for a latent inflammatory potential of adult hippocampal neural progenitors and identify
as a critical regulator that facilitates adult neurogenesis via proactive suppression of this detrimental potential.</description><identifier>ISSN: 2375-2548</identifier><identifier>EISSN: 2375-2548</identifier><identifier>DOI: 10.1126/sciadv.abf5606</identifier><identifier>PMID: 34020954</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>Animals ; Cellular Neuroscience ; Dentate Gyrus ; Inflammation - genetics ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Neural Stem Cells ; Neurogenesis ; Neuroscience ; SciAdv r-articles ; Transcription Factor 4 - genetics</subject><ispartof>Science advances, 2021-05, Vol.7 (21)</ispartof><rights>Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).</rights><rights>Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). 2021 The Authors</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-362170005f19da3b43b86ff82a8c041ebe6983ea7c2595b8b505708b5db1fa473</citedby><cites>FETCH-LOGICAL-c390t-362170005f19da3b43b86ff82a8c041ebe6983ea7c2595b8b505708b5db1fa473</cites><orcidid>0000-0003-4766-6793 ; 0000-0003-1140-7853 ; 0000-0001-6224-1043 ; 0000-0002-1684-5468</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139598/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139598/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34020954$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shariq, Mohammad</creatorcontrib><creatorcontrib>Sahasrabuddhe, Vinaya</creatorcontrib><creatorcontrib>Krishna, Sreevatsan</creatorcontrib><creatorcontrib>Radha, Swathi</creatorcontrib><creatorcontrib>Nruthyathi</creatorcontrib><creatorcontrib>Bellampalli, Ravishankara</creatorcontrib><creatorcontrib>Dwivedi, Anukriti</creatorcontrib><creatorcontrib>Cheramangalam, Rajit</creatorcontrib><creatorcontrib>Reizis, Boris</creatorcontrib><creatorcontrib>Hébert, Jean</creatorcontrib><creatorcontrib>Ghosh, Hiyaa S</creatorcontrib><title>Adult neural stem cells have latent inflammatory potential that is kept suppressed by Tcf4 to facilitate adult neurogenesis</title><title>Science advances</title><addtitle>Sci Adv</addtitle><description>Inflammation is known to adversely affect adult neurogenesis, wherein the source of inflammation is largely thought to be extraneous to the neurogenic niche. Here, we demonstrate that the adult hippocampal neural progenitors harbor an inflammatory potential that is proactively suppressed by transcription factor 4 (
). Deletion of
in hippocampal
-expressing progenitors causes loss of proliferative capacity and acquisition of myeloid inflammatory properties. This transformation abolishes their differentiation potential and causes production of detrimental factors that adversely affect niche cells, causing inflammation in the dentate gyrus. Thus, on one hand,
deletion causes abrogation of proliferative progenitors leading to reduction of adult neurogenesis, while on the other, their accompanying inflammatory transformation inflicts inflammation in the niche. Taken together, we provide the first evidence for a latent inflammatory potential of adult hippocampal neural progenitors and identify
as a critical regulator that facilitates adult neurogenesis via proactive suppression of this detrimental potential.</description><subject>Animals</subject><subject>Cellular Neuroscience</subject><subject>Dentate Gyrus</subject><subject>Inflammation - genetics</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Transgenic</subject><subject>Neural Stem Cells</subject><subject>Neurogenesis</subject><subject>Neuroscience</subject><subject>SciAdv r-articles</subject><subject>Transcription Factor 4 - genetics</subject><issn>2375-2548</issn><issn>2375-2548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUU1rGzEQFaElCW6uPRYde7Gjz_24FEJok0Kgl_QsRtpRrHZ3tV1pDaZ_PjJ2TXqaYebNmzfzCPnI2YZzUd0mF6DbbcB6XbHqglwLWeu10Kp59ya_Ijcp_WKMcVVVmreX5EoqJlir1TX5e9ctfaYjLjP0NGUcqMO-T3QLO6Q9ZBwzDaPvYRggx3lPp3iohYLOWyi9RH_jlGlapmnGlLCjdk-fnVc0R-rBhT7kQkPhvCi-4IgppA_kvYc-4c0prsjPb1-f7x_XTz8evt_fPa2dbFley0rwusjXnrcdSKukbSrvGwGNY4qjxaptJELthG61baxmumYldJZ7ULVckS9H3mmxA3auyC_HmmkOA8x7EyGY_ztj2JqXuDMNl60u3Cvy-UQwxz8LpmyGkA5vghHjkozQkgslisQC3Ryhbo4pzejPazgzB9PM0TRzMq0MfHor7gz_Z5F8BUMCl_U</recordid><startdate>20210501</startdate><enddate>20210501</enddate><creator>Shariq, Mohammad</creator><creator>Sahasrabuddhe, Vinaya</creator><creator>Krishna, Sreevatsan</creator><creator>Radha, Swathi</creator><creator>Nruthyathi</creator><creator>Bellampalli, Ravishankara</creator><creator>Dwivedi, Anukriti</creator><creator>Cheramangalam, Rajit</creator><creator>Reizis, Boris</creator><creator>Hébert, Jean</creator><creator>Ghosh, Hiyaa S</creator><general>American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4766-6793</orcidid><orcidid>https://orcid.org/0000-0003-1140-7853</orcidid><orcidid>https://orcid.org/0000-0001-6224-1043</orcidid><orcidid>https://orcid.org/0000-0002-1684-5468</orcidid></search><sort><creationdate>20210501</creationdate><title>Adult neural stem cells have latent inflammatory potential that is kept suppressed by Tcf4 to facilitate adult neurogenesis</title><author>Shariq, Mohammad ; Sahasrabuddhe, Vinaya ; Krishna, Sreevatsan ; Radha, Swathi ; Nruthyathi ; Bellampalli, Ravishankara ; Dwivedi, Anukriti ; Cheramangalam, Rajit ; Reizis, Boris ; Hébert, Jean ; Ghosh, Hiyaa S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-362170005f19da3b43b86ff82a8c041ebe6983ea7c2595b8b505708b5db1fa473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Cellular Neuroscience</topic><topic>Dentate Gyrus</topic><topic>Inflammation - genetics</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Transgenic</topic><topic>Neural Stem Cells</topic><topic>Neurogenesis</topic><topic>Neuroscience</topic><topic>SciAdv r-articles</topic><topic>Transcription Factor 4 - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shariq, Mohammad</creatorcontrib><creatorcontrib>Sahasrabuddhe, Vinaya</creatorcontrib><creatorcontrib>Krishna, Sreevatsan</creatorcontrib><creatorcontrib>Radha, Swathi</creatorcontrib><creatorcontrib>Nruthyathi</creatorcontrib><creatorcontrib>Bellampalli, Ravishankara</creatorcontrib><creatorcontrib>Dwivedi, Anukriti</creatorcontrib><creatorcontrib>Cheramangalam, Rajit</creatorcontrib><creatorcontrib>Reizis, Boris</creatorcontrib><creatorcontrib>Hébert, Jean</creatorcontrib><creatorcontrib>Ghosh, Hiyaa S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Science advances</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shariq, Mohammad</au><au>Sahasrabuddhe, Vinaya</au><au>Krishna, Sreevatsan</au><au>Radha, Swathi</au><au>Nruthyathi</au><au>Bellampalli, Ravishankara</au><au>Dwivedi, Anukriti</au><au>Cheramangalam, Rajit</au><au>Reizis, Boris</au><au>Hébert, Jean</au><au>Ghosh, Hiyaa S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adult neural stem cells have latent inflammatory potential that is kept suppressed by Tcf4 to facilitate adult neurogenesis</atitle><jtitle>Science advances</jtitle><addtitle>Sci Adv</addtitle><date>2021-05-01</date><risdate>2021</risdate><volume>7</volume><issue>21</issue><issn>2375-2548</issn><eissn>2375-2548</eissn><abstract>Inflammation is known to adversely affect adult neurogenesis, wherein the source of inflammation is largely thought to be extraneous to the neurogenic niche. Here, we demonstrate that the adult hippocampal neural progenitors harbor an inflammatory potential that is proactively suppressed by transcription factor 4 (
). Deletion of
in hippocampal
-expressing progenitors causes loss of proliferative capacity and acquisition of myeloid inflammatory properties. This transformation abolishes their differentiation potential and causes production of detrimental factors that adversely affect niche cells, causing inflammation in the dentate gyrus. Thus, on one hand,
deletion causes abrogation of proliferative progenitors leading to reduction of adult neurogenesis, while on the other, their accompanying inflammatory transformation inflicts inflammation in the niche. Taken together, we provide the first evidence for a latent inflammatory potential of adult hippocampal neural progenitors and identify
as a critical regulator that facilitates adult neurogenesis via proactive suppression of this detrimental potential.</abstract><cop>United States</cop><pub>American Association for the Advancement of Science</pub><pmid>34020954</pmid><doi>10.1126/sciadv.abf5606</doi><orcidid>https://orcid.org/0000-0003-4766-6793</orcidid><orcidid>https://orcid.org/0000-0003-1140-7853</orcidid><orcidid>https://orcid.org/0000-0001-6224-1043</orcidid><orcidid>https://orcid.org/0000-0002-1684-5468</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2375-2548 |
| ispartof | Science advances, 2021-05, Vol.7 (21) |
| issn | 2375-2548 2375-2548 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8139598 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Cellular Neuroscience Dentate Gyrus Inflammation - genetics Mice Mice, Inbred C57BL Mice, Transgenic Neural Stem Cells Neurogenesis Neuroscience SciAdv r-articles Transcription Factor 4 - genetics |
| title | Adult neural stem cells have latent inflammatory potential that is kept suppressed by Tcf4 to facilitate adult neurogenesis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-10T08%3A39%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Adult%20neural%20stem%20cells%20have%20latent%20inflammatory%20potential%20that%20is%20kept%20suppressed%20by%20Tcf4%20to%20facilitate%20adult%20neurogenesis&rft.jtitle=Science%20advances&rft.au=Shariq,%20Mohammad&rft.date=2021-05-01&rft.volume=7&rft.issue=21&rft.issn=2375-2548&rft.eissn=2375-2548&rft_id=info:doi/10.1126/sciadv.abf5606&rft_dat=%3Cproquest_pubme%3E2531242005%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2531242005&rft_id=info:pmid/34020954&rfr_iscdi=true |