A CDC7 inhibitor sensitizes DNA-damaging chemotherapies by suppressing homologous recombination repair to delay DNA damage recovery

Cell division cycle 7 (CDC7), a serine/threonine kinase, plays important roles in DNA replication. We developed a highly specific CDC7 inhibitor, TAK-931, as a clinical cancer therapeutic agent. This study aimed to identify the potential combination partners of TAK-931 for guiding its clinical devel...

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Veröffentlicht in:	Science advances 2021-05, Vol.7 (21)
Hauptverfasser:	Iwai, Kenichi, Nambu, Tadahiro, Kashima, Yukie, Yu, Jie, Eng, Kurt, Miyamoto, Kazumasa, Kakoi, Kazuyo, Gotou, Masamitsu, Takeuchi, Toshiyuki, Kogame, Akifumi, Sappal, Jessica, Murai, Saomi, Haeno, Hiroshi, Kageyama, Shun-Ichiro, Kurasawa, Osamu, Niu, Huifeng, Kannan, Karuppiah, Ohashi, Akihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Biology Cell Cycle Proteins - metabolism Cell Line, Tumor DNA DNA Damage Humans Neoplasms - drug therapy Neoplasms - genetics Protein Serine-Threonine Kinases Recombinational DNA Repair SciAdv r-articles
Online-Zugang:	Volltext
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