A retrospective analysis of 12,400 SARS-CoV-2 RNA tests in patients with COVID-19 in Wuhan
The outbreak and widely spread of coronavirus disease 2019 (COVID-19) has become a global public health concern. COVID-19 has caused an unprecedented and profound impact on the whole world, and the prevention and control of COVID-19 is a global public health challenge remains to be solved. The retro...
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| Veröffentlicht in: | Medicine (Baltimore) 2021-05, Vol.100 (20), p.e25916-e25916 |
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| creator | Wang, Jingwei Bao, Anyu Gu, Jian He, Xiaoyun Wu, Zegang Qiao, Bin Chen, Zhen Xiong, Liang Zhang, Yan Zheng, Hongyun Li, Feng Zhao, Zhijun Mei, Siqing Tong, Yongqing |
| description | The outbreak and widely spread of coronavirus disease 2019 (COVID-19) has become a global public health concern. COVID-19 has caused an unprecedented and profound impact on the whole world, and the prevention and control of COVID-19 is a global public health challenge remains to be solved. The retrospective analysis of the large scale tests of SARS-CoV-2 RNA may indicate some important information of this pandemic. We selected 12400 SARS-CoV-2 tests detected in Wuhan in the first semester of 2020 and made a systematic analysis of them, in order to find some beneficial clue for the consistent prevention and control of COVID-19.SARS-CoV-2 RNA was detected in suspected COVID-19 patients with real-time fluorescence quantitative PCR (RT-qPCR). The patients' features including gender, age, type of specimen, source of patients, and the dynamic changes of the clinical symptoms were recorded and statistically analyzed. Quantitative and qualitive statistical analysis were carried out after laboratory detection.The positive rate of SARS-CoV-2 was 33.02% in 12,400 suspected patients' specimens in Wuhan at the first months of COVID-19 epidemics. SARS-CoV-2 RT-qPCR test of nasopharyngeal swabs might produce 4.79% (594/12400) presumptive results. The positive rate of SARS-CoV-2 RNA was significantly different between gender, age, type of specimen, source of patients, respectively (P < .05). The median window period from the occurrence of clinical symptom or close contact with COVID-19 patient to the first detection of positive PCR was 2 days (interquartile range, 1-4 days). The median interval time from the first SARS-CoV-2 positive to the turning negative was 14 days (interquartile range, 8-19.25 days).This study reveals the comprehensive characteristics of the SARS-CoV-2 RNA detection from multiple perspectives, and it provides important clues and may also supply useful suggestions for future work of the prevention and treatment of COVID-19. |
| doi_str_mv | 10.1097/MD.0000000000025916 |
| format | Article |
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COVID-19 has caused an unprecedented and profound impact on the whole world, and the prevention and control of COVID-19 is a global public health challenge remains to be solved. The retrospective analysis of the large scale tests of SARS-CoV-2 RNA may indicate some important information of this pandemic. We selected 12400 SARS-CoV-2 tests detected in Wuhan in the first semester of 2020 and made a systematic analysis of them, in order to find some beneficial clue for the consistent prevention and control of COVID-19.SARS-CoV-2 RNA was detected in suspected COVID-19 patients with real-time fluorescence quantitative PCR (RT-qPCR). The patients' features including gender, age, type of specimen, source of patients, and the dynamic changes of the clinical symptoms were recorded and statistically analyzed. Quantitative and qualitive statistical analysis were carried out after laboratory detection.The positive rate of SARS-CoV-2 was 33.02% in 12,400 suspected patients' specimens in Wuhan at the first months of COVID-19 epidemics. SARS-CoV-2 RT-qPCR test of nasopharyngeal swabs might produce 4.79% (594/12400) presumptive results. The positive rate of SARS-CoV-2 RNA was significantly different between gender, age, type of specimen, source of patients, respectively (P < .05). The median window period from the occurrence of clinical symptom or close contact with COVID-19 patient to the first detection of positive PCR was 2 days (interquartile range, 1-4 days). The median interval time from the first SARS-CoV-2 positive to the turning negative was 14 days (interquartile range, 8-19.25 days).This study reveals the comprehensive characteristics of the SARS-CoV-2 RNA detection from multiple perspectives, and it provides important clues and may also supply useful suggestions for future work of the prevention and treatment of COVID-19.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000025916</identifier><identifier>PMID: 34011059</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins</publisher><subject>Adult ; Aged ; China - epidemiology ; COVID-19 - diagnosis ; COVID-19 - epidemiology ; COVID-19 Nucleic Acid Testing - methods ; COVID-19 Nucleic Acid Testing - statistics & numerical data ; Female ; Humans ; Male ; Middle Aged ; Nasopharynx - virology ; Observational Study ; Real-Time Polymerase Chain Reaction - methods ; Real-Time Polymerase Chain Reaction - statistics & numerical data ; Retrospective Studies ; RNA, Viral - analysis ; SARS-CoV-2 - genetics</subject><ispartof>Medicine (Baltimore), 2021-05, Vol.100 (20), p.e25916-e25916</ispartof><rights>Lippincott Williams & Wilkins</rights><rights>Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.</rights><rights>Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4500-debf6ce713537c37840cf6ddb7cba53aa450418dd4fd75b3f530455ed2096e6d3</citedby><cites>FETCH-LOGICAL-c4500-debf6ce713537c37840cf6ddb7cba53aa450418dd4fd75b3f530455ed2096e6d3</cites><orcidid>0000-0002-1051-5054</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137137/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137137/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34011059$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Jingwei</creatorcontrib><creatorcontrib>Bao, Anyu</creatorcontrib><creatorcontrib>Gu, Jian</creatorcontrib><creatorcontrib>He, Xiaoyun</creatorcontrib><creatorcontrib>Wu, Zegang</creatorcontrib><creatorcontrib>Qiao, Bin</creatorcontrib><creatorcontrib>Chen, Zhen</creatorcontrib><creatorcontrib>Xiong, Liang</creatorcontrib><creatorcontrib>Zhang, Yan</creatorcontrib><creatorcontrib>Zheng, Hongyun</creatorcontrib><creatorcontrib>Li, Feng</creatorcontrib><creatorcontrib>Zhao, Zhijun</creatorcontrib><creatorcontrib>Mei, Siqing</creatorcontrib><creatorcontrib>Tong, Yongqing</creatorcontrib><title>A retrospective analysis of 12,400 SARS-CoV-2 RNA tests in patients with COVID-19 in Wuhan</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>The outbreak and widely spread of coronavirus disease 2019 (COVID-19) has become a global public health concern. COVID-19 has caused an unprecedented and profound impact on the whole world, and the prevention and control of COVID-19 is a global public health challenge remains to be solved. The retrospective analysis of the large scale tests of SARS-CoV-2 RNA may indicate some important information of this pandemic. We selected 12400 SARS-CoV-2 tests detected in Wuhan in the first semester of 2020 and made a systematic analysis of them, in order to find some beneficial clue for the consistent prevention and control of COVID-19.SARS-CoV-2 RNA was detected in suspected COVID-19 patients with real-time fluorescence quantitative PCR (RT-qPCR). The patients' features including gender, age, type of specimen, source of patients, and the dynamic changes of the clinical symptoms were recorded and statistically analyzed. Quantitative and qualitive statistical analysis were carried out after laboratory detection.The positive rate of SARS-CoV-2 was 33.02% in 12,400 suspected patients' specimens in Wuhan at the first months of COVID-19 epidemics. SARS-CoV-2 RT-qPCR test of nasopharyngeal swabs might produce 4.79% (594/12400) presumptive results. The positive rate of SARS-CoV-2 RNA was significantly different between gender, age, type of specimen, source of patients, respectively (P < .05). The median window period from the occurrence of clinical symptom or close contact with COVID-19 patient to the first detection of positive PCR was 2 days (interquartile range, 1-4 days). The median interval time from the first SARS-CoV-2 positive to the turning negative was 14 days (interquartile range, 8-19.25 days).This study reveals the comprehensive characteristics of the SARS-CoV-2 RNA detection from multiple perspectives, and it provides important clues and may also supply useful suggestions for future work of the prevention and treatment of COVID-19.</description><subject>Adult</subject><subject>Aged</subject><subject>China - epidemiology</subject><subject>COVID-19 - diagnosis</subject><subject>COVID-19 - epidemiology</subject><subject>COVID-19 Nucleic Acid Testing - methods</subject><subject>COVID-19 Nucleic Acid Testing - statistics & numerical data</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nasopharynx - virology</subject><subject>Observational Study</subject><subject>Real-Time Polymerase Chain Reaction - methods</subject><subject>Real-Time Polymerase Chain Reaction - statistics & numerical data</subject><subject>Retrospective Studies</subject><subject>RNA, Viral - analysis</subject><subject>SARS-CoV-2 - genetics</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkdtuEzEQhi0EoqHwBEjIl1zg4uM6vkGKEiiVWiq1UCRuLK89yxo2u6m926hvX4eUcrBsjTXzze_xDEIvGT1i1Oi3Z6sj-mdxZVj1CM2YEhVRppKP0WznJdpoeYCe5fyDUiY0l0_RgZCUMarMDH1b4ARjGvIG_BhvALvedbc5Zjw0mPE3klJ8ubi4JMvhinB88WmBR8hjxrHHGzdG6Mt9G8cWL8-vTlaEmV3k69S6_jl60rguw4t7e4i-fHj_efmRnJ4fnywXp8RLRSkJUDeVB82EEtoLPZfUN1UItfa1U8K5Qkk2D0E2QataNEpQqRQETk0FVRCH6N1edzPVawi-lJRcZzcprl26tYOL9t9IH1v7fbix89KOsovA63uBNFxP5Xd2HbOHrnM9DFO2XHFjGGdsh4o96kvLcoLm4RlG7W4q9mxl_59KyXr1d4UPOb_HUAC5B7ZDN0LKP7tpC8m24Lqx_aWntOGEU17wckjxSCruAPlclRA</recordid><startdate>20210521</startdate><enddate>20210521</enddate><creator>Wang, Jingwei</creator><creator>Bao, Anyu</creator><creator>Gu, Jian</creator><creator>He, Xiaoyun</creator><creator>Wu, Zegang</creator><creator>Qiao, Bin</creator><creator>Chen, Zhen</creator><creator>Xiong, Liang</creator><creator>Zhang, Yan</creator><creator>Zheng, Hongyun</creator><creator>Li, Feng</creator><creator>Zhao, Zhijun</creator><creator>Mei, Siqing</creator><creator>Tong, Yongqing</creator><general>Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1051-5054</orcidid></search><sort><creationdate>20210521</creationdate><title>A retrospective analysis of 12,400 SARS-CoV-2 RNA tests in patients with COVID-19 in Wuhan</title><author>Wang, Jingwei ; Bao, Anyu ; Gu, Jian ; He, Xiaoyun ; Wu, Zegang ; Qiao, Bin ; Chen, Zhen ; Xiong, Liang ; Zhang, Yan ; Zheng, Hongyun ; Li, Feng ; Zhao, Zhijun ; Mei, Siqing ; Tong, Yongqing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4500-debf6ce713537c37840cf6ddb7cba53aa450418dd4fd75b3f530455ed2096e6d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Aged</topic><topic>China - epidemiology</topic><topic>COVID-19 - diagnosis</topic><topic>COVID-19 - epidemiology</topic><topic>COVID-19 Nucleic Acid Testing - methods</topic><topic>COVID-19 Nucleic Acid Testing - statistics & numerical data</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nasopharynx - virology</topic><topic>Observational Study</topic><topic>Real-Time Polymerase Chain Reaction - methods</topic><topic>Real-Time Polymerase Chain Reaction - statistics & numerical data</topic><topic>Retrospective Studies</topic><topic>RNA, Viral - analysis</topic><topic>SARS-CoV-2 - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Jingwei</creatorcontrib><creatorcontrib>Bao, Anyu</creatorcontrib><creatorcontrib>Gu, Jian</creatorcontrib><creatorcontrib>He, Xiaoyun</creatorcontrib><creatorcontrib>Wu, Zegang</creatorcontrib><creatorcontrib>Qiao, Bin</creatorcontrib><creatorcontrib>Chen, Zhen</creatorcontrib><creatorcontrib>Xiong, Liang</creatorcontrib><creatorcontrib>Zhang, Yan</creatorcontrib><creatorcontrib>Zheng, Hongyun</creatorcontrib><creatorcontrib>Li, Feng</creatorcontrib><creatorcontrib>Zhao, Zhijun</creatorcontrib><creatorcontrib>Mei, Siqing</creatorcontrib><creatorcontrib>Tong, Yongqing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Jingwei</au><au>Bao, Anyu</au><au>Gu, Jian</au><au>He, Xiaoyun</au><au>Wu, Zegang</au><au>Qiao, Bin</au><au>Chen, Zhen</au><au>Xiong, Liang</au><au>Zhang, Yan</au><au>Zheng, Hongyun</au><au>Li, Feng</au><au>Zhao, Zhijun</au><au>Mei, Siqing</au><au>Tong, Yongqing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A retrospective analysis of 12,400 SARS-CoV-2 RNA tests in patients with COVID-19 in Wuhan</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2021-05-21</date><risdate>2021</risdate><volume>100</volume><issue>20</issue><spage>e25916</spage><epage>e25916</epage><pages>e25916-e25916</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>The outbreak and widely spread of coronavirus disease 2019 (COVID-19) has become a global public health concern. COVID-19 has caused an unprecedented and profound impact on the whole world, and the prevention and control of COVID-19 is a global public health challenge remains to be solved. The retrospective analysis of the large scale tests of SARS-CoV-2 RNA may indicate some important information of this pandemic. We selected 12400 SARS-CoV-2 tests detected in Wuhan in the first semester of 2020 and made a systematic analysis of them, in order to find some beneficial clue for the consistent prevention and control of COVID-19.SARS-CoV-2 RNA was detected in suspected COVID-19 patients with real-time fluorescence quantitative PCR (RT-qPCR). The patients' features including gender, age, type of specimen, source of patients, and the dynamic changes of the clinical symptoms were recorded and statistically analyzed. Quantitative and qualitive statistical analysis were carried out after laboratory detection.The positive rate of SARS-CoV-2 was 33.02% in 12,400 suspected patients' specimens in Wuhan at the first months of COVID-19 epidemics. SARS-CoV-2 RT-qPCR test of nasopharyngeal swabs might produce 4.79% (594/12400) presumptive results. The positive rate of SARS-CoV-2 RNA was significantly different between gender, age, type of specimen, source of patients, respectively (P < .05). The median window period from the occurrence of clinical symptom or close contact with COVID-19 patient to the first detection of positive PCR was 2 days (interquartile range, 1-4 days). The median interval time from the first SARS-CoV-2 positive to the turning negative was 14 days (interquartile range, 8-19.25 days).This study reveals the comprehensive characteristics of the SARS-CoV-2 RNA detection from multiple perspectives, and it provides important clues and may also supply useful suggestions for future work of the prevention and treatment of COVID-19.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins</pub><pmid>34011059</pmid><doi>10.1097/MD.0000000000025916</doi><orcidid>https://orcid.org/0000-0002-1051-5054</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wolters Kluwer Open Health; IngentaConnect Free/Open Access Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Aged China - epidemiology COVID-19 - diagnosis COVID-19 - epidemiology COVID-19 Nucleic Acid Testing - methods COVID-19 Nucleic Acid Testing - statistics & numerical data Female Humans Male Middle Aged Nasopharynx - virology Observational Study Real-Time Polymerase Chain Reaction - methods Real-Time Polymerase Chain Reaction - statistics & numerical data Retrospective Studies RNA, Viral - analysis SARS-CoV-2 - genetics |
| title | A retrospective analysis of 12,400 SARS-CoV-2 RNA tests in patients with COVID-19 in Wuhan |
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