Bioenergetic and inflammatory systemic phenotypes in Alzheimer’s disease APOE ε4‐carriers

We examined the impact of an APOE ε4 genotype on Alzheimer's disease (AD) subject platelet and lymphocyte metabolism. Mean platelet mitochondrial cytochrome oxidase Vmax activity was lower in APOE ε4 carriers and lymphocyte Annexin V, a marker of apoptosis, was significantly higher. Proteins th...

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Veröffentlicht in:	Aging cell 2021-05, Vol.20 (5), p.e13356-n/a
Hauptverfasser:	Wilkins, Heather M., Wang, Xiaowan, Menta, Blaise W., Koppel, Scott J., Bothwell, Rebecca, Becker, Annette M., Anderson, Heidi, Schwartz, Erin, Pei, Dong, Yellapu, Nanda K., Chalise, Prabhakar, Gouvion, Cynthia M., Haeri, Mohammad, Burns, Jeffrey M., Swerdlow, Russell H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Advertising executives Aged Aged, 80 and over Alzheimer Disease - enzymology Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer's disease Annexin V APOE Apolipoprotein E Apolipoproteins Apolipoproteins E - genetics Apolipoproteins E - metabolism Apoptosis Bioenergetics Biomarkers Blood Blood platelets Blood Platelets - enzymology Brain Cavitation Cells, Cultured Cholesterol Cytochrome Development and progression Electron Transport Complex IV - metabolism Energy Metabolism Etiology Female Flow cytometry Genetic aspects Genotypes Health risk assessment Heterozygote Human subjects Humans Inflammation Inflammation Mediators - metabolism Lymphocytes Lymphocytes - metabolism Male Metabolism Mitochondria Neurodegenerative diseases Original Oxidases Phenotype Phenotypes Phlebotomy Physiological aspects Platelets Proteins RNA sequencing RNA-Seq
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