Functional coordination of BET family proteins underlies altered transcription associated with memory impairment in fragile X syndrome

Bromodomain and extraterminal proteins (BET) are epigenetic readers that play critical roles in gene regulation. Pharmacologic inhibition of the bromodomain present in all BET family members is a promising therapeutic strategy for various diseases, but its impact on individual family members has not...

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Veröffentlicht in:	Science advances 2021-05, Vol.7 (21)
Hauptverfasser:	Kim, Seung-Kyoon, Liu, Xihui, Park, Jongmin, Um, Dahun, Kilaru, Gokhul, Chiang, Cheng-Ming, Kang, Mingon, Huber, Kimberly M, Kang, Keunsoo, Kim, Tae-Kyung
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Fragile X Syndrome - genetics Gene Expression Regulation Histones - metabolism Mice Molecular Biology Neuroscience Nuclear Proteins - genetics Nuclear Proteins - metabolism SciAdv r-articles Transcription Factors - genetics Transcription Factors - metabolism
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