Efficient Differentiation of Human Induced Pluripotent Stem Cells into Endothelial Cells under Xenogeneic-free Conditions for Vascular Tissue Engineering

Tissue engineered vascular grafts (TEVGs) represent a promising therapeutic option for emergency vascular intervention. Although the application of small-diameter TEVGs using patient-specific primary endothelial cells (ECs) to prevent thrombosis and occlusion prior to implantation could be hindered...

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Veröffentlicht in:	Acta biomaterialia 2021-01, Vol.119, p.184-196
Hauptverfasser:	Luo, Jiesi, Shi, Xiangyu, Lin, Yuyao, Yuan, Yifan, Kural, Mehmet H., Wang, Juan, Ellis, Matthew W., Anderson, Christopher W., Zhang, Shang-Min, Riaz, Muhammad, Niklason, Laura E., Qyang, Yibing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bioreactors Blood Vessel Prosthesis Cell culture Cell Differentiation Differentiation Endothelial Cells Gene expression Human induced pluripotent stem cells Humans Immune response Induced Pluripotent Stem Cells Occlusion Pluripotency Reagents Shear stress Stem cell transplantation Stem cells Thromboembolism Thrombosis Tissue Engineering Vascular tissue vascular tissue engineering xenogeneic-free Xenografts
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