An Aromatic Cluster in the Active Site of epi-Isozizaene Synthase Is an Electrostatic Toggle for Divergent Terpene Cyclization Pathways

The sesquiterpene cyclase epi-isozizaene synthase (EIZS) catalyzes the cyclization of farnesyl diphosphate to form the tricyclic precursor of the antibiotic albaflavenone. The hydrophobic active site is largely defined by aromatic residues that direct a multistep reaction sequence through multiple c...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemistry (Easton) 2020-12, Vol.59 (50), p.4744-4754
Hauptverfasser:	Ronnebaum, Trey A, Gardner, Sarah M, Christianson, David W
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Carbon-Carbon Lyases - chemistry Carbon-Carbon Lyases - genetics Carbon-Carbon Lyases - metabolism Catalytic Domain Crystallography, X-Ray Cyclization Models, Molecular Mutagenesis, Site-Directed Protein Conformation Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Sesquiterpenes - chemistry Sesquiterpenes - metabolism Static Electricity Stereoisomerism Streptomyces coelicolor - enzymology Streptomyces coelicolor - genetics Substrate Specificity Terpenes - chemistry Terpenes - metabolism Water - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!