MicroRNA155 Plays a Critical Role in the Pathogenesis of Cutaneous Leishmania major Infection by Promoting a Th2 Response and Attenuating Dendritic Cell Activity

Interferon (IFN)-γ is indispensable in the resolution of cutaneous leishmaniasis (CL), while the Th2 cytokines IL-4, IL-10, and IL-13 mediate susceptibility. A recent study found that miR155, which promotes CD4+ Th1 response and IFN-γ production, is dispensable in the control of Leishmania donovani...

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Veröffentlicht in:	The American journal of pathology 2021-05, Vol.191 (5), p.809-816
Hauptverfasser:	Varikuti, Sanjay, Verma, Chaitenya, Natarajan, Gayathri, Oghumu, Steve, Satoskar, Abhay R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD8-Positive T-Lymphocytes - immunology Cytokines - immunology Dendritic Cells - immunology Female Killer Cells, Natural - immunology Leishmania major - immunology Leishmania major - pathogenicity Leishmaniasis, Cutaneous - immunology Leishmaniasis, Cutaneous - parasitology Mice Mice, Inbred C57BL MicroRNAs - genetics Short Communication Th2 Cells - immunology
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