In vitro generation of peri-islet basement membrane-like structures

The peri-islet extracellular matrix (ECM) is a key component of the microenvironmental niche surrounding pancreatic islets of Langerhans. The cell anchorage and signaling provided by the peri-islet ECM is critical for optimum beta cell glucose responsiveness, but islets lose this important native EC...

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Veröffentlicht in:	Biomaterials 2021-06, Vol.273, p.120808-120808, Article 120808
Hauptverfasser:	Santini-González, Jorge, Simonovich, Jennifer A., Castro-Gutiérrez, Roberto, González-Vargas, Yarelis, Abuid, Nicholas J., Stabler, Cherie L., Russ, Holger A., Phelps, Edward A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basement Membrane Collagen Type IV Extracellular Matrix Islets of Langerhans Islets of Langerhans Transplantation Laminin Laminin-nidogen-collagen IV Pancreatic islet Rats Stem cell-derived beta cell Type 1 diabetes
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