A participant-derived xenograft model of HIV enables long-term evaluation of autologous immunotherapies

HIV-specific CD8+ T cells partially control viral replication and delay disease progression, but they rarely provide lasting protection, largely due to immune escape. Here, we show that engrafting mice with memory CD4+ T cells from HIV+ donors uniquely allows for the in vivo evaluation of autologous...

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Veröffentlicht in:	The Journal of experimental medicine 2021-07, Vol.218 (7)
Hauptverfasser:	McCann, Chase D, van Dorp, Christiaan H, Danesh, Ali, Ward, Adam R, Dilling, Thomas R, Mota, Talia M, Zale, Elizabeth, Stevenson, Eva M, Patel, Shabnum, Brumme, Chanson J, Dong, Winnie, Jones, Douglas S, Andresen, Thomas L, Walker, Bruce D, Brumme, Zabrina L, Bollard, Catherine M, Perelson, Alan S, Irvine, Darrell J, Jones, R Brad
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Animals CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Cell Line HEK293 Cells Heterografts - immunology Heterografts - virology HIV Infections - immunology HIV Infections - virology HIV-1 - immunology host defense Humans Immunodeficiency Immunotherapy - methods Infectious disease Infectious Disease and Host Defense Interleukin-15 - immunology Mice Mutation - immunology Technical Advances and Resources Viremia - immunology Viremia - virology Virus Replication - immunology
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