High Levels of Psychological Resilience Associated With Less Disease Activity, Better Quality of Life, and Fewer Surgeries in Inflammatory Bowel Disease
Abstract Background Stress and depression are risk factors for inflammatory bowel disease (IBD) exacerbations. It is unknown if resilience, or one’s ability to recover from adversity, impacts disease course. The aim of this study was to examine the association between resilience and IBD disease acti...
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| Veröffentlicht in: | Inflammatory bowel diseases 2021-05, Vol.27 (6), p.791-796 |
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| creator | Sehgal, Priya Ungaro, Ryan C Foltz, Carol Iacoviello, Brian Dubinsky, Marla C Keefer, Laurie |
| description | Abstract
Background
Stress and depression are risk factors for inflammatory bowel disease (IBD) exacerbations. It is unknown if resilience, or one’s ability to recover from adversity, impacts disease course. The aim of this study was to examine the association between resilience and IBD disease activity, quality of life (QoL), and IBD-related surgeries.
Methods
We performed a cross-sectional study of IBD patients at an academic center. Patients completed the Connor-Davidson Resilience Scale questionnaire, which measures resilience (high resilience score ≥ 35). The primary outcome was IBD disease activity, measured by Mayo score and Harvey-Bradshaw Index (HBI). The QoL and IBD-related surgeries were also assessed. Multivariate linear regression was conducted to assess the association of high resilience with disease activity and QoL.
Results
Our patient sample comprised 92 patients with ulcerative colitis (UC) and 137 patients with Crohn disease (CD). High resilience was noted in 27% of patients with UC and 21.5% of patients with CD. Among patients with UC, those with high resilience had a mean Mayo score of 1.54, and those with low resilience had a mean Mayo score of 4.31, P < 0.001. Among patients with CD, those with high resilience had a mean HBI of 2.31, and those with low resilience had a mean HBI of 3.95, P = 0.035. In multivariable analysis, high resilience was independently associated with lower disease activity in both UC (P < 0.001) and CD (P = 0.037) and with higher QoL (P = 0.016). High resilience was also associated with fewer surgeries (P = 0.001) among patients with CD.
Conclusions
High resilience was independently associated with lower disease activity and better QoL in patients with IBD and fewer IBD surgeries in patients with CD. These findings suggest that resilience may be a modifiable factor that can risk-stratify patients with IBD prone to poor outcomes. |
| doi_str_mv | 10.1093/ibd/izaa196 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8128407</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/ibd/izaa196</oup_id><sourcerecordid>2426175122</sourcerecordid><originalsourceid>FETCH-LOGICAL-c412t-88b09efb96b73e52e353edec0cf09e52ca64e37069b1a31bb87390634dae88a53</originalsourceid><addsrcrecordid>eNp9kUtr3DAURk1padKkq-6LVqXQuNHDlqVNII-mCQykT7oUsnw9oyJbU0meMPkl_bnVMJPQbMJd6HHPPRJ8RfGG4I8ES3Zs2-7Y3mlNJH9W7JOa8bISVfU873EjSiyl2CtexfgbY5pLviz2GOUyF98v_l7Z-QLNYAUuIt-jL3FtFt75uTXaoW8QrbMwGkCnMXpjdYIO_bJpMxIjurARdMxNk-zKpvUROoOUIKCvk3b5vDHObA9HSI8duoTb3Po-hTkECxHZEV2PvdPDoJMPa3Tmb8HdOw-LF712EV7v1oPi5-WnH-dX5ezm8_X56aw0FaGpFKLFEvpW8rZhUFNgNYMODDZ9vq-p0bwC1mAuW6IZaVvRMIk5qzoNQuiaHRQnW-9yagfoDIwpaKeWwQ46rJXXVj3ujHah5n6lBKGiwk0WvN8Jgv8zQUxqsNGAc3oEP0VFK8pJUxNKM_phi5rgYwzQPzxDsNpkqXKWapdlpt_-_7MH9j68DLzbAn5aPmn6B7QXq9E</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2426175122</pqid></control><display><type>article</type><title>High Levels of Psychological Resilience Associated With Less Disease Activity, Better Quality of Life, and Fewer Surgeries in Inflammatory Bowel Disease</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><creator>Sehgal, Priya ; Ungaro, Ryan C ; Foltz, Carol ; Iacoviello, Brian ; Dubinsky, Marla C ; Keefer, Laurie</creator><creatorcontrib>Sehgal, Priya ; Ungaro, Ryan C ; Foltz, Carol ; Iacoviello, Brian ; Dubinsky, Marla C ; Keefer, Laurie</creatorcontrib><description>Abstract
Background
Stress and depression are risk factors for inflammatory bowel disease (IBD) exacerbations. It is unknown if resilience, or one’s ability to recover from adversity, impacts disease course. The aim of this study was to examine the association between resilience and IBD disease activity, quality of life (QoL), and IBD-related surgeries.
Methods
We performed a cross-sectional study of IBD patients at an academic center. Patients completed the Connor-Davidson Resilience Scale questionnaire, which measures resilience (high resilience score ≥ 35). The primary outcome was IBD disease activity, measured by Mayo score and Harvey-Bradshaw Index (HBI). The QoL and IBD-related surgeries were also assessed. Multivariate linear regression was conducted to assess the association of high resilience with disease activity and QoL.
Results
Our patient sample comprised 92 patients with ulcerative colitis (UC) and 137 patients with Crohn disease (CD). High resilience was noted in 27% of patients with UC and 21.5% of patients with CD. Among patients with UC, those with high resilience had a mean Mayo score of 1.54, and those with low resilience had a mean Mayo score of 4.31, P < 0.001. Among patients with CD, those with high resilience had a mean HBI of 2.31, and those with low resilience had a mean HBI of 3.95, P = 0.035. In multivariable analysis, high resilience was independently associated with lower disease activity in both UC (P < 0.001) and CD (P = 0.037) and with higher QoL (P = 0.016). High resilience was also associated with fewer surgeries (P = 0.001) among patients with CD.
Conclusions
High resilience was independently associated with lower disease activity and better QoL in patients with IBD and fewer IBD surgeries in patients with CD. These findings suggest that resilience may be a modifiable factor that can risk-stratify patients with IBD prone to poor outcomes.</description><identifier>ISSN: 1078-0998</identifier><identifier>EISSN: 1536-4844</identifier><identifier>DOI: 10.1093/ibd/izaa196</identifier><identifier>PMID: 32696966</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Chronic Disease ; Clinical Research ; Colitis, Ulcerative - psychology ; Colitis, Ulcerative - surgery ; Crohn Disease - psychology ; Crohn Disease - surgery ; Cross-Sectional Studies ; Humans ; Quality of Life ; Resilience, Psychological ; Severity of Illness Index</subject><ispartof>Inflammatory bowel diseases, 2021-05, Vol.27 (6), p.791-796</ispartof><rights>The Author(s) 2020. Published by Oxford University Press on behalf of Crohn’s & Colitis Foundation. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2020</rights><rights>2020 Crohn’s & Colitis Foundation. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-88b09efb96b73e52e353edec0cf09e52ca64e37069b1a31bb87390634dae88a53</citedby><cites>FETCH-LOGICAL-c412t-88b09efb96b73e52e353edec0cf09e52ca64e37069b1a31bb87390634dae88a53</cites><orcidid>0000-0003-2611-2767</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,1584,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32696966$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sehgal, Priya</creatorcontrib><creatorcontrib>Ungaro, Ryan C</creatorcontrib><creatorcontrib>Foltz, Carol</creatorcontrib><creatorcontrib>Iacoviello, Brian</creatorcontrib><creatorcontrib>Dubinsky, Marla C</creatorcontrib><creatorcontrib>Keefer, Laurie</creatorcontrib><title>High Levels of Psychological Resilience Associated With Less Disease Activity, Better Quality of Life, and Fewer Surgeries in Inflammatory Bowel Disease</title><title>Inflammatory bowel diseases</title><addtitle>Inflamm Bowel Dis</addtitle><description>Abstract
Background
Stress and depression are risk factors for inflammatory bowel disease (IBD) exacerbations. It is unknown if resilience, or one’s ability to recover from adversity, impacts disease course. The aim of this study was to examine the association between resilience and IBD disease activity, quality of life (QoL), and IBD-related surgeries.
Methods
We performed a cross-sectional study of IBD patients at an academic center. Patients completed the Connor-Davidson Resilience Scale questionnaire, which measures resilience (high resilience score ≥ 35). The primary outcome was IBD disease activity, measured by Mayo score and Harvey-Bradshaw Index (HBI). The QoL and IBD-related surgeries were also assessed. Multivariate linear regression was conducted to assess the association of high resilience with disease activity and QoL.
Results
Our patient sample comprised 92 patients with ulcerative colitis (UC) and 137 patients with Crohn disease (CD). High resilience was noted in 27% of patients with UC and 21.5% of patients with CD. Among patients with UC, those with high resilience had a mean Mayo score of 1.54, and those with low resilience had a mean Mayo score of 4.31, P < 0.001. Among patients with CD, those with high resilience had a mean HBI of 2.31, and those with low resilience had a mean HBI of 3.95, P = 0.035. In multivariable analysis, high resilience was independently associated with lower disease activity in both UC (P < 0.001) and CD (P = 0.037) and with higher QoL (P = 0.016). High resilience was also associated with fewer surgeries (P = 0.001) among patients with CD.
Conclusions
High resilience was independently associated with lower disease activity and better QoL in patients with IBD and fewer IBD surgeries in patients with CD. These findings suggest that resilience may be a modifiable factor that can risk-stratify patients with IBD prone to poor outcomes.</description><subject>Chronic Disease</subject><subject>Clinical Research</subject><subject>Colitis, Ulcerative - psychology</subject><subject>Colitis, Ulcerative - surgery</subject><subject>Crohn Disease - psychology</subject><subject>Crohn Disease - surgery</subject><subject>Cross-Sectional Studies</subject><subject>Humans</subject><subject>Quality of Life</subject><subject>Resilience, Psychological</subject><subject>Severity of Illness Index</subject><issn>1078-0998</issn><issn>1536-4844</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtr3DAURk1padKkq-6LVqXQuNHDlqVNII-mCQykT7oUsnw9oyJbU0meMPkl_bnVMJPQbMJd6HHPPRJ8RfGG4I8ES3Zs2-7Y3mlNJH9W7JOa8bISVfU873EjSiyl2CtexfgbY5pLviz2GOUyF98v_l7Z-QLNYAUuIt-jL3FtFt75uTXaoW8QrbMwGkCnMXpjdYIO_bJpMxIjurARdMxNk-zKpvUROoOUIKCvk3b5vDHObA9HSI8duoTb3Po-hTkECxHZEV2PvdPDoJMPa3Tmb8HdOw-LF712EV7v1oPi5-WnH-dX5ezm8_X56aw0FaGpFKLFEvpW8rZhUFNgNYMODDZ9vq-p0bwC1mAuW6IZaVvRMIk5qzoNQuiaHRQnW-9yagfoDIwpaKeWwQ46rJXXVj3ujHah5n6lBKGiwk0WvN8Jgv8zQUxqsNGAc3oEP0VFK8pJUxNKM_phi5rgYwzQPzxDsNpkqXKWapdlpt_-_7MH9j68DLzbAn5aPmn6B7QXq9E</recordid><startdate>20210517</startdate><enddate>20210517</enddate><creator>Sehgal, Priya</creator><creator>Ungaro, Ryan C</creator><creator>Foltz, Carol</creator><creator>Iacoviello, Brian</creator><creator>Dubinsky, Marla C</creator><creator>Keefer, Laurie</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2611-2767</orcidid></search><sort><creationdate>20210517</creationdate><title>High Levels of Psychological Resilience Associated With Less Disease Activity, Better Quality of Life, and Fewer Surgeries in Inflammatory Bowel Disease</title><author>Sehgal, Priya ; Ungaro, Ryan C ; Foltz, Carol ; Iacoviello, Brian ; Dubinsky, Marla C ; Keefer, Laurie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-88b09efb96b73e52e353edec0cf09e52ca64e37069b1a31bb87390634dae88a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Chronic Disease</topic><topic>Clinical Research</topic><topic>Colitis, Ulcerative - psychology</topic><topic>Colitis, Ulcerative - surgery</topic><topic>Crohn Disease - psychology</topic><topic>Crohn Disease - surgery</topic><topic>Cross-Sectional Studies</topic><topic>Humans</topic><topic>Quality of Life</topic><topic>Resilience, Psychological</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sehgal, Priya</creatorcontrib><creatorcontrib>Ungaro, Ryan C</creatorcontrib><creatorcontrib>Foltz, Carol</creatorcontrib><creatorcontrib>Iacoviello, Brian</creatorcontrib><creatorcontrib>Dubinsky, Marla C</creatorcontrib><creatorcontrib>Keefer, Laurie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Inflammatory bowel diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sehgal, Priya</au><au>Ungaro, Ryan C</au><au>Foltz, Carol</au><au>Iacoviello, Brian</au><au>Dubinsky, Marla C</au><au>Keefer, Laurie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High Levels of Psychological Resilience Associated With Less Disease Activity, Better Quality of Life, and Fewer Surgeries in Inflammatory Bowel Disease</atitle><jtitle>Inflammatory bowel diseases</jtitle><addtitle>Inflamm Bowel Dis</addtitle><date>2021-05-17</date><risdate>2021</risdate><volume>27</volume><issue>6</issue><spage>791</spage><epage>796</epage><pages>791-796</pages><issn>1078-0998</issn><eissn>1536-4844</eissn><abstract>Abstract
Background
Stress and depression are risk factors for inflammatory bowel disease (IBD) exacerbations. It is unknown if resilience, or one’s ability to recover from adversity, impacts disease course. The aim of this study was to examine the association between resilience and IBD disease activity, quality of life (QoL), and IBD-related surgeries.
Methods
We performed a cross-sectional study of IBD patients at an academic center. Patients completed the Connor-Davidson Resilience Scale questionnaire, which measures resilience (high resilience score ≥ 35). The primary outcome was IBD disease activity, measured by Mayo score and Harvey-Bradshaw Index (HBI). The QoL and IBD-related surgeries were also assessed. Multivariate linear regression was conducted to assess the association of high resilience with disease activity and QoL.
Results
Our patient sample comprised 92 patients with ulcerative colitis (UC) and 137 patients with Crohn disease (CD). High resilience was noted in 27% of patients with UC and 21.5% of patients with CD. Among patients with UC, those with high resilience had a mean Mayo score of 1.54, and those with low resilience had a mean Mayo score of 4.31, P < 0.001. Among patients with CD, those with high resilience had a mean HBI of 2.31, and those with low resilience had a mean HBI of 3.95, P = 0.035. In multivariable analysis, high resilience was independently associated with lower disease activity in both UC (P < 0.001) and CD (P = 0.037) and with higher QoL (P = 0.016). High resilience was also associated with fewer surgeries (P = 0.001) among patients with CD.
Conclusions
High resilience was independently associated with lower disease activity and better QoL in patients with IBD and fewer IBD surgeries in patients with CD. These findings suggest that resilience may be a modifiable factor that can risk-stratify patients with IBD prone to poor outcomes.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>32696966</pmid><doi>10.1093/ibd/izaa196</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-2611-2767</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Inflammatory bowel diseases, 2021-05, Vol.27 (6), p.791-796 |
| issn | 1078-0998 1536-4844 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Chronic Disease Clinical Research Colitis, Ulcerative - psychology Colitis, Ulcerative - surgery Crohn Disease - psychology Crohn Disease - surgery Cross-Sectional Studies Humans Quality of Life Resilience, Psychological Severity of Illness Index |
| title | High Levels of Psychological Resilience Associated With Less Disease Activity, Better Quality of Life, and Fewer Surgeries in Inflammatory Bowel Disease |
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