Identification of EMT signaling cross-talk and gene regulatory networks by single-cell RNA sequencing

The epithelial-to-mesenchymal transition (EMT) plays a critical role during normal development and in cancer progression. EMT is induced by various signaling pathways, including TGF-β, BMP,Wnt–β-catenin, NOTCH, Shh, and receptor tyrosine kinases. In this study, we performed single-cell RNA sequencin...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2021-05, Vol.118 (19), p.1-10
Hauptverfasser:	Deshmukh, Abhijeet P., Vasaikar, Suhas V., Tomczak, Katarzyna, Tripathi, Shubham, den Hollander, Petra, Arslan, Emre, Chakraborty, Priyanka, Soundararajan, Rama, Jolly, Mohit Kumar, Rai, Kunal, Levine, Herbert, Mani, Sendurai A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Cancer Cell Line Circuits Clustering Crosstalk Epithelial Cells - drug effects Epithelial Cells - metabolism Epithelial-Mesenchymal Transition - drug effects Epithelial-Mesenchymal Transition - genetics Gene expression Gene Expression Profiling - methods Gene Expression Profiling - statistics & numerical data Gene Regulatory Networks Gene sequencing Humans Kaplan-Meier Estimate Kinases Mesenchyme MicroRNAs - genetics miRNA Neoplasms - classification Neoplasms - genetics Perturbation Prognosis Proportional Hazards Models Ribonucleic acid RNA RNA-Seq - methods Signal transduction Signal Transduction - drug effects Signal Transduction - genetics Signaling Single-Cell Analysis - methods Transcription factors Transforming Growth Factor beta1 - metabolism Transforming Growth Factor beta1 - pharmacology Transforming growth factor-b1 Tyrosine Wnt protein β-Catenin
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