Clinical Pattern of Preoperative Positron Emission Tomography/Computed Tomography (PET/CT) Can Predict the Aggressive Behavior of Resected Solid Pseudopapillary Neoplasm of the Pancreas
Predicting the aggressiveness of solid pseudopapillary neoplasms (SPNs) remains an important goal. The present study aimed to identify perioperative factors that can predict patients who will develop clinically aggressive SPN. Records of individuals with pathologically confirmed SPN from 2006 to 201...
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| Veröffentlicht in: | Cancers 2021-04, Vol.13 (9), p.2119 |
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| creator | Kim, Ji-Su Hao, Emmanuel Ii-Uy Rho, Seoung-Yoon Hwang, Ho-Kyoung Lee, Woo-Jung Yoon, Dong-Sub Kang, Chang-Moo |
| description | Predicting the aggressiveness of solid pseudopapillary neoplasms (SPNs) remains an important goal. The present study aimed to identify perioperative factors that can predict patients who will develop clinically aggressive SPN. Records of individuals with pathologically confirmed SPN from 2006 to 2017 were obtained from the patient registry database of Yonsei University, Severance Hospital. For this study, aggressive behavior was defined as SPN that had recurred, metastasized, or involved adjacent organs. A total of 98 patients diagnosed with SPNs were analyzed retrospectively. Of these, 10 were reported to have SPNs with aggressive characteristics. We found that age (≥40 years;
= 0.039), symptomatic presentation (
= 0.001), tumor size (>10 cm;
< 0.001), positron emission tomography/computed tomography (PET/CT) classification (
< 0.001), and lymphovascular invasion (
= 0.003) were significantly correlated with aggressive behavior of SPNs. Multivariate analysis showed that PET/CT configuration (
= 0.002) (exp(β)111.353 (95% confidence interval (CI): 5.960-2081), age ≥40 years (
= 0.015) (exp(β) 23.242 (95% CI: 1.854-291.4)), and lymphovascular invasion (
= 0.021) (exp(β) 22.511 (95% CI: 1.595-317.6)) were the only independent factors associated with aggressive SPN. Our data suggest that age ≥40 years, PET/CT Type III configuration, and lymphovascular invasion are independent factors associated with aggressive SPN. This information can help clinicians develop individualized management and surveillance plans to manage patients more effectively. |
| doi_str_mv | 10.3390/cancers13092119 |
| format | Article |
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= 0.039), symptomatic presentation (
= 0.001), tumor size (>10 cm;
< 0.001), positron emission tomography/computed tomography (PET/CT) classification (
< 0.001), and lymphovascular invasion (
= 0.003) were significantly correlated with aggressive behavior of SPNs. Multivariate analysis showed that PET/CT configuration (
= 0.002) (exp(β)111.353 (95% confidence interval (CI): 5.960-2081), age ≥40 years (
= 0.015) (exp(β) 23.242 (95% CI: 1.854-291.4)), and lymphovascular invasion (
= 0.021) (exp(β) 22.511 (95% CI: 1.595-317.6)) were the only independent factors associated with aggressive SPN. Our data suggest that age ≥40 years, PET/CT Type III configuration, and lymphovascular invasion are independent factors associated with aggressive SPN. This information can help clinicians develop individualized management and surveillance plans to manage patients more effectively.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers13092119</identifier><identifier>PMID: 33925678</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Age ; Classification ; Computed tomography ; Magnetic resonance imaging ; Multivariate analysis ; Pancreas ; Patients ; Positron emission tomography ; Surgical outcomes ; Tumors ; Variables</subject><ispartof>Cancers, 2021-04, Vol.13 (9), p.2119</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-e52256da1d17b04fdc3fa0115b720d94aba918f45eb98d5dbe7fa1ff2b1fe89c3</citedby><cites>FETCH-LOGICAL-c421t-e52256da1d17b04fdc3fa0115b720d94aba918f45eb98d5dbe7fa1ff2b1fe89c3</cites><orcidid>0000-0002-9501-9665 ; 0000-0002-5382-4658 ; 0000-0002-1265-826X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125428/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125428/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33925678$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Ji-Su</creatorcontrib><creatorcontrib>Hao, Emmanuel Ii-Uy</creatorcontrib><creatorcontrib>Rho, Seoung-Yoon</creatorcontrib><creatorcontrib>Hwang, Ho-Kyoung</creatorcontrib><creatorcontrib>Lee, Woo-Jung</creatorcontrib><creatorcontrib>Yoon, Dong-Sub</creatorcontrib><creatorcontrib>Kang, Chang-Moo</creatorcontrib><title>Clinical Pattern of Preoperative Positron Emission Tomography/Computed Tomography (PET/CT) Can Predict the Aggressive Behavior of Resected Solid Pseudopapillary Neoplasm of the Pancreas</title><title>Cancers</title><addtitle>Cancers (Basel)</addtitle><description>Predicting the aggressiveness of solid pseudopapillary neoplasms (SPNs) remains an important goal. The present study aimed to identify perioperative factors that can predict patients who will develop clinically aggressive SPN. Records of individuals with pathologically confirmed SPN from 2006 to 2017 were obtained from the patient registry database of Yonsei University, Severance Hospital. For this study, aggressive behavior was defined as SPN that had recurred, metastasized, or involved adjacent organs. A total of 98 patients diagnosed with SPNs were analyzed retrospectively. Of these, 10 were reported to have SPNs with aggressive characteristics. We found that age (≥40 years;
= 0.039), symptomatic presentation (
= 0.001), tumor size (>10 cm;
< 0.001), positron emission tomography/computed tomography (PET/CT) classification (
< 0.001), and lymphovascular invasion (
= 0.003) were significantly correlated with aggressive behavior of SPNs. Multivariate analysis showed that PET/CT configuration (
= 0.002) (exp(β)111.353 (95% confidence interval (CI): 5.960-2081), age ≥40 years (
= 0.015) (exp(β) 23.242 (95% CI: 1.854-291.4)), and lymphovascular invasion (
= 0.021) (exp(β) 22.511 (95% CI: 1.595-317.6)) were the only independent factors associated with aggressive SPN. Our data suggest that age ≥40 years, PET/CT Type III configuration, and lymphovascular invasion are independent factors associated with aggressive SPN. This information can help clinicians develop individualized management and surveillance plans to manage patients more effectively.</description><subject>Age</subject><subject>Classification</subject><subject>Computed tomography</subject><subject>Magnetic resonance imaging</subject><subject>Multivariate analysis</subject><subject>Pancreas</subject><subject>Patients</subject><subject>Positron emission tomography</subject><subject>Surgical outcomes</subject><subject>Tumors</subject><subject>Variables</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkk9v1DAQxS0EolXpmRuyxKUclrWdZONckEq0_JEqiGA5RxN7vOsqiYPtrNSPxrfDUUu11BeP7Dc_v2cNIa85e59lFVsrGBX6wDNWCc6rZ-RcsFKsNpsqf35Sn5HLEG5ZWlnGy035kpyldlFsSnlO_tS9Ha2CnjYQI_qROkMbj25CD9EekTYu2OjdSLeDDcGmYucGt_cwHe7WtRumOaI-OaNXzXa3rnfvaA3jgtJWRRoPSK_3e48JkaAf8QBH6_zy2g8MqBbGT9dbTZuAs3YTTLbvwd_Rb8lLD2FYpAulSak9QnhFXhjoA14-7Bfk16ftrv6yuvn--Wt9fbNSueBxhYVIUTVwzcuO5UarzADjvOhKwXSVQwcVlyYvsKukLnSHpQFujOi4QVmp7IJ8uOdOczegVjhGD307eTske60D2_5_M9pDu3fHVnJR5EImwNUDwLvfM4bYpo9UmNKN6ObQikIwWbCS8yR9-0R662Y_pniLSiYel0VSre9VyrsQPJpHM5y1y2S0TyYjdbw5zfCo_zcH2V9Rr7qF</recordid><startdate>20210427</startdate><enddate>20210427</enddate><creator>Kim, Ji-Su</creator><creator>Hao, Emmanuel Ii-Uy</creator><creator>Rho, Seoung-Yoon</creator><creator>Hwang, Ho-Kyoung</creator><creator>Lee, Woo-Jung</creator><creator>Yoon, Dong-Sub</creator><creator>Kang, Chang-Moo</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9501-9665</orcidid><orcidid>https://orcid.org/0000-0002-5382-4658</orcidid><orcidid>https://orcid.org/0000-0002-1265-826X</orcidid></search><sort><creationdate>20210427</creationdate><title>Clinical Pattern of Preoperative Positron Emission Tomography/Computed Tomography (PET/CT) Can Predict the Aggressive Behavior of Resected Solid Pseudopapillary Neoplasm of the Pancreas</title><author>Kim, Ji-Su ; Hao, Emmanuel Ii-Uy ; Rho, Seoung-Yoon ; Hwang, Ho-Kyoung ; Lee, Woo-Jung ; Yoon, Dong-Sub ; Kang, Chang-Moo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-e52256da1d17b04fdc3fa0115b720d94aba918f45eb98d5dbe7fa1ff2b1fe89c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Age</topic><topic>Classification</topic><topic>Computed tomography</topic><topic>Magnetic resonance imaging</topic><topic>Multivariate analysis</topic><topic>Pancreas</topic><topic>Patients</topic><topic>Positron emission tomography</topic><topic>Surgical outcomes</topic><topic>Tumors</topic><topic>Variables</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Ji-Su</creatorcontrib><creatorcontrib>Hao, Emmanuel Ii-Uy</creatorcontrib><creatorcontrib>Rho, Seoung-Yoon</creatorcontrib><creatorcontrib>Hwang, Ho-Kyoung</creatorcontrib><creatorcontrib>Lee, Woo-Jung</creatorcontrib><creatorcontrib>Yoon, Dong-Sub</creatorcontrib><creatorcontrib>Kang, Chang-Moo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Ji-Su</au><au>Hao, Emmanuel Ii-Uy</au><au>Rho, Seoung-Yoon</au><au>Hwang, Ho-Kyoung</au><au>Lee, Woo-Jung</au><au>Yoon, Dong-Sub</au><au>Kang, Chang-Moo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical Pattern of Preoperative Positron Emission Tomography/Computed Tomography (PET/CT) Can Predict the Aggressive Behavior of Resected Solid Pseudopapillary Neoplasm of the Pancreas</atitle><jtitle>Cancers</jtitle><addtitle>Cancers (Basel)</addtitle><date>2021-04-27</date><risdate>2021</risdate><volume>13</volume><issue>9</issue><spage>2119</spage><pages>2119-</pages><issn>2072-6694</issn><eissn>2072-6694</eissn><abstract>Predicting the aggressiveness of solid pseudopapillary neoplasms (SPNs) remains an important goal. The present study aimed to identify perioperative factors that can predict patients who will develop clinically aggressive SPN. Records of individuals with pathologically confirmed SPN from 2006 to 2017 were obtained from the patient registry database of Yonsei University, Severance Hospital. For this study, aggressive behavior was defined as SPN that had recurred, metastasized, or involved adjacent organs. A total of 98 patients diagnosed with SPNs were analyzed retrospectively. Of these, 10 were reported to have SPNs with aggressive characteristics. We found that age (≥40 years;
= 0.039), symptomatic presentation (
= 0.001), tumor size (>10 cm;
< 0.001), positron emission tomography/computed tomography (PET/CT) classification (
< 0.001), and lymphovascular invasion (
= 0.003) were significantly correlated with aggressive behavior of SPNs. Multivariate analysis showed that PET/CT configuration (
= 0.002) (exp(β)111.353 (95% confidence interval (CI): 5.960-2081), age ≥40 years (
= 0.015) (exp(β) 23.242 (95% CI: 1.854-291.4)), and lymphovascular invasion (
= 0.021) (exp(β) 22.511 (95% CI: 1.595-317.6)) were the only independent factors associated with aggressive SPN. Our data suggest that age ≥40 years, PET/CT Type III configuration, and lymphovascular invasion are independent factors associated with aggressive SPN. This information can help clinicians develop individualized management and surveillance plans to manage patients more effectively.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>33925678</pmid><doi>10.3390/cancers13092119</doi><orcidid>https://orcid.org/0000-0002-9501-9665</orcidid><orcidid>https://orcid.org/0000-0002-5382-4658</orcidid><orcidid>https://orcid.org/0000-0002-1265-826X</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Cancers, 2021-04, Vol.13 (9), p.2119 |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Age Classification Computed tomography Magnetic resonance imaging Multivariate analysis Pancreas Patients Positron emission tomography Surgical outcomes Tumors Variables |
| title | Clinical Pattern of Preoperative Positron Emission Tomography/Computed Tomography (PET/CT) Can Predict the Aggressive Behavior of Resected Solid Pseudopapillary Neoplasm of the Pancreas |
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