Preferential Expression of Programmed Death Ligand 1 Protein in Tumor-Associated Macrophages and Its Potential Role in Immunotherapy for Hepatocellular Carcinoma

A predictive biomarker of immune checkpoint inhibitor (ICI)-based treatments in hepatocellular carcinoma (HCC) has not been clearly demonstrated. In this study, we focused on the infiltration and programmed death ligand 1 (PD-L1) expression of tumor-associated macrophages (TAMs) in the tumor microen...

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Veröffentlicht in:	International journal of molecular sciences 2021-04, Vol.22 (9), p.4710
Hauptverfasser:	Park, Dong-Jun, Sung, Pil-Soo, Lee, Gil-Won, Cho, Sungwoo, Kim, Sung-Min, Kang, Byung-Yoon, Hur, Wonhee, Yang, Hyun, Lee, Soon-Kyu, Lee, Sung-Hak, Jung, Eun-Sun, Seo, Chang-Ho, Ahn, Joseph, Choi, Ho-Joong, You, Young-Kyoung, Jang, Jeong-Won, Bae, Si-Hyun, Choi, Jong-Young, Yoon, Seung-Kew
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antineoplastic Agents, Immunological - pharmacology Antineoplastic Agents, Immunological - therapeutic use Apoptosis B7-H1 Antigen - antagonists & inhibitors B7-H1 Antigen - biosynthesis B7-H1 Antigen - genetics Carcinoma, Hepatocellular - immunology Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - therapy CD4 antigen CD8 antigen Cell culture Cell size Coculture Techniques Experiments Gene Expression Regulation, Neoplastic - drug effects Hepatocellular carcinoma Humans Immune checkpoint inhibitors Immune Checkpoint Inhibitors - pharmacology Immune Checkpoint Inhibitors - therapeutic use Immunoglobulin G Immunohistochemistry Immunotherapy Immunotherapy - methods Ki-67 Antigen - biosynthesis Ki-67 Antigen - genetics Kinases Ligands Liver cancer Liver Neoplasms - immunology Liver Neoplasms - pathology Liver Neoplasms - therapy Liver Neoplasms, Experimental - immunology Lymphocytes Lymphocytes T Lymphocytes, Tumor-Infiltrating - immunology Macrophages Medical prognosis Metastases Mice Mice, Inbred C57BL Molecular Targeted Therapy - methods Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Nivolumab - pharmacology Nivolumab - therapeutic use Patients PD-1 protein PD-L1 protein Pretreatment Spleen T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism Tumor cells Tumor Cells, Cultured Tumor microenvironment Tumor Microenvironment - immunology Tumor-Associated Macrophages - drug effects Tumor-Associated Macrophages - metabolism Tumors
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