Stem Cell Therapy for Modulating Neuroinflammation in Neuropathic Pain
Neuropathic pain (NP) is a complex, debilitating, chronic pain state, heterogeneous in nature and caused by a lesion or disease affecting the somatosensory system. Its pathogenesis involves a wide range of molecular pathways. NP treatment is extremely challenging, due to its complex underlying disea...
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| Veröffentlicht in: | International journal of molecular sciences 2021-05, Vol.22 (9), p.4853 |
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| creator | Joshi, Hari Prasad Jo, Hyun-Jung Kim, Yong-Ho An, Seong-Bae Park, Chul-Kyu Han, Inbo |
| description | Neuropathic pain (NP) is a complex, debilitating, chronic pain state, heterogeneous in nature and caused by a lesion or disease affecting the somatosensory system. Its pathogenesis involves a wide range of molecular pathways. NP treatment is extremely challenging, due to its complex underlying disease mechanisms. Current pharmacological and nonpharmacological approaches can provide long-lasting pain relief to a limited percentage of patients and lack safe and effective treatment options. Therefore, scientists are focusing on the introduction of novel treatment approaches, such as stem cell therapy. A growing number of reports have highlighted the potential of stem cells for treating NP. In this review, we briefly introduce NP, current pharmacological and nonpharmacological treatments, and preclinical studies of stem cells to treat NP. In addition, we summarize stem cell mechanisms—including neuromodulation in treating NP. Literature searches were conducted using PubMed to provide an overview of the neuroprotective effects of stem cells with particular emphasis on recent translational research regarding stem cell-based treatment of NP, highlighting its potential as a novel therapeutic approach. |
| doi_str_mv | 10.3390/ijms22094853 |
| format | Article |
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Its pathogenesis involves a wide range of molecular pathways. NP treatment is extremely challenging, due to its complex underlying disease mechanisms. Current pharmacological and nonpharmacological approaches can provide long-lasting pain relief to a limited percentage of patients and lack safe and effective treatment options. Therefore, scientists are focusing on the introduction of novel treatment approaches, such as stem cell therapy. A growing number of reports have highlighted the potential of stem cells for treating NP. In this review, we briefly introduce NP, current pharmacological and nonpharmacological treatments, and preclinical studies of stem cells to treat NP. In addition, we summarize stem cell mechanisms—including neuromodulation in treating NP. 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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-51e6558f4c3322610aa776c8316054b3e21e009478d5cceccc4747f24c733bb23</citedby><cites>FETCH-LOGICAL-c422t-51e6558f4c3322610aa776c8316054b3e21e009478d5cceccc4747f24c733bb23</cites><orcidid>0000-0001-8704-3553 ; 0000-0002-4152-3022 ; 0000-0001-9885-1468 ; 0000-0002-0834-9325 ; 0000-0002-3157-2832 ; 0000-0002-3706-2075</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124149/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124149/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids></links><search><creatorcontrib>Joshi, Hari Prasad</creatorcontrib><creatorcontrib>Jo, Hyun-Jung</creatorcontrib><creatorcontrib>Kim, Yong-Ho</creatorcontrib><creatorcontrib>An, Seong-Bae</creatorcontrib><creatorcontrib>Park, Chul-Kyu</creatorcontrib><creatorcontrib>Han, Inbo</creatorcontrib><title>Stem Cell Therapy for Modulating Neuroinflammation in Neuropathic Pain</title><title>International journal of molecular sciences</title><description>Neuropathic pain (NP) is a complex, debilitating, chronic pain state, heterogeneous in nature and caused by a lesion or disease affecting the somatosensory system. 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| subjects | Cell therapy Chemokines Chronic pain Cytokines Disease Drugs Immune system Inflammation Kinases Literature reviews Lymphocytes Morphine Nervous system Neuromodulation Neurons Neuroprotection Neutrophils Pain Pathogenesis Pharmacology Review Signal transduction Somatosensory system Spinal cord Stem cells |
| title | Stem Cell Therapy for Modulating Neuroinflammation in Neuropathic Pain |
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