TLR4-Mediated Recognition of Mouse Polyomavirus Promotes Cancer-Associated Fibroblast-Like Phenotype and Cell Invasiveness

The tumorigenic potential of mouse polyomavirus (MPyV) has been studied for decades in cell culture models and has been mainly attributed to nonstructural middle T antigen (MT), which acts as a scaffold signal adaptor, activates Src tyrosine kinases, and possesses transforming ability. We hypothesiz...

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Veröffentlicht in:	Cancers 2021-04, Vol.13 (9), p.2076
Hauptverfasser:	Janovec, Vaclav, Ryabchenko, Boris, Škarková, Aneta, Pokorná, Karolína, Rösel, Daniel, Brábek, Jan, Weber, Jan, Forstová, Jitka, Hirsch, Ivan, Huérfano, Sandra
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Cancer Capsid protein Cell activation Cell culture Chemokines Cytokines Embryo fibroblasts Fibroblasts Immune response Infections Inflammation Innate immunity Interleukin 6 Invasiveness Kinases Microenvironments Monoclonal antibodies Monocyte chemoattractant protein 1 Phenotypes Phosphorylation Polyclonal antibodies Replication Stat3 protein TLR4 protein Toll-like receptors Tumorigenesis Tyrosine Viral infections Viruses VP1 protein
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