The HSV-1 Transcription Factor ICP4 Confers Liquid-Like Properties to Viral Replication Compartments

Herpes Simplex Virus Type-1 (HSV-1) forms progeny in the nucleus within distinct membrane-less inclusions, the viral replication compartments (VRCs), where viral gene expression, DNA replication, and packaging occur. The way in which the VRCs maintain spatial integrity remains unresolved. Here, we d...

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Veröffentlicht in:	International journal of molecular sciences 2021-04, Vol.22 (9), p.4447
Hauptverfasser:	Seyffert, Michael, Georgi, Fanny, Tobler, Kurt, Bourqui, Laurent, Anfossi, Michela, Michaelsen, Kevin, Vogt, Bernd, Greber, Urs F, Fraefel, Cornel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell culture Cell Nucleus - metabolism Chlorocebus aethiops Compartments Condensates Cytoplasm Deoxyribonucleic acid DNA DNA biosynthesis Fluorescence Fluorescence recovery after photobleaching Gene expression Gene Expression Regulation, Viral Genomes Herpes simplex Herpes Simplex - genetics Herpes Simplex - metabolism Herpes Simplex - virology Herpes viruses Herpesvirus 1, Human - physiology Immediate-Early Proteins - genetics Immediate-Early Proteins - metabolism Inclusion bodies Inclusions Intrinsically Disordered Proteins - genetics Intrinsically Disordered Proteins - metabolism Liquid phases Liquid-Liquid Extraction Nuclei (cytology) Packaging Phase separation Phase Transition Photobleaching Plasmids Progeny Proteins Replication Transcription factors Vero Cells Viral Replication Compartments
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