KLVS heterozygosity reduces brain amyloid in asymptomatic at- risk APOE4 carriers

KLOTHO*VS heterozygosity ( KL *VS HET+ ) was recently shown to be associated with reduced risk of Alzheimer’s disease (AD) in APOE *4 carriers. Additional studies suggest that KL *VS HET+ protects against amyloid burden in cognitively normal older subjects, but sample sizes were too small to draw de...

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Veröffentlicht in:	Neurobiology of aging 2021-05, Vol.101, p.123-129
Hauptverfasser:	Belloy, Michael E., Eger, Sarah J., Le Guen, Yann, Napolioni, Valerio, Deters, Kacie D., Yang, Hyun-Sik, Scelsi, Marzia A., Porter, Tenielle, James, Sarah-Naomi, Wong, Andrew, Schott, Jonathan M., Sperling, Reisa A., Laws, Simon M., Mormino, Elisabeth C., He, Zihuai, Han, Summer S., Altmann, Andre, Greicius, Michael D.
Format:	Artikel
Sprache:	eng
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