Efficacy of a low-dose candidate malaria vaccine, R21 in adjuvant Matrix-M, with seasonal administration to children in Burkina Faso: a randomised controlled trial

Stalled progress in controlling Plasmodium falciparum malaria highlights the need for an effective and deployable vaccine. RTS,S/AS01, the most effective malaria vaccine candidate to date, demonstrated 56% efficacy over 12 months in African children. We therefore assessed a new candidate vaccine for...

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Veröffentlicht in:The Lancet (British edition) 2021-05, Vol.397 (10287), p.1809-1818
Hauptverfasser: Datoo, Mehreen S, Natama, Magloire H, Somé, Athanase, Traoré, Ousmane, Rouamba, Toussaint, Bellamy, Duncan, Yameogo, Prisca, Valia, Daniel, Tegneri, Moubarak, Ouedraogo, Florence, Soma, Rachidatou, Sawadogo, Seydou, Sorgho, Faizatou, Derra, Karim, Rouamba, Eli, Orindi, Benedict, Ramos Lopez, Fernando, Flaxman, Amy, Cappuccini, Federica, Kailath, Reshma, Elias, Sean, Mukhopadhyay, Ekta, Noe, Andres, Cairns, Matthew, Lawrie, Alison, Roberts, Rachel, Valéa, Innocent, Sorgho, Hermann, Williams, Nicola, Glenn, Gregory, Fries, Louis, Reimer, Jenny, Ewer, Katie J, Shaligram, Umesh, Hill, Adrian V S, Tinto, Halidou
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