Cork-in-bottle mechanism of inhibitor binding to mammalian complex I

Mitochondrial complex I (NADH:ubiquinone oxidoreductase), a major contributor of free energy for oxidative phosphorylation, is increasingly recognized as a promising drug target for ischemia-reperfusion injury, metabolic disorders, and various cancers. Several pharmacologically relevant but structur...

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Veröffentlicht in:	Science advances 2021-05, Vol.7 (20), Article 4000
Hauptverfasser:	Chung, Injae, Serreli, Riccardo, Cross, Jason B., Di Francesco, M. Emilia, Marszalek, Joseph R., Hirst, Judy
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Multidisciplinary Sciences SciAdv r-articles Science & Technology Science & Technology - Other Topics Structural Biology
Online-Zugang:	Volltext
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