Tumor-Specific T Cells Exacerbate Mortality and Immune Dysregulation during Sepsis

Sepsis induces significant immune dysregulation characterized by lymphocyte apoptosis and alterations in the cytokine milieu. Because cancer patients exhibit a 10-fold greater risk of developing sepsis compared with the general population, we aimed to understand how pre-existing malignancy alters se...

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Veröffentlicht in:	The Journal of immunology (1950) 2021-05, Vol.206 (10), p.2412-2419
Hauptverfasser:	Chen, Ching-Wen, Bennion, Kelsey B, Swift, David A, Morrow, Kristen N, Zhang, Wenxiao, Oami, Takehiko, Coopersmith, Craig M, Ford, Mandy L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - immunology CD8-Positive T-Lymphocytes - immunology Cell Line, Tumor Cytokines - blood Immunity Interferon-gamma - metabolism Lung Neoplasms - blood Lung Neoplasms - complications Lung Neoplasms - immunology Lymph Nodes - immunology Male Melanoma, Experimental - blood Melanoma, Experimental - complications Melanoma, Experimental - immunology Mice Mice, Inbred C57BL Mice, Transgenic Phenotype Sepsis - blood Sepsis - complications Sepsis - immunology Sepsis - mortality Skin Neoplasms - blood Skin Neoplasms - complications Skin Neoplasms - immunology Spleen - immunology Thy-1 Antigens - genetics
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