Apilimod alters TGFβ signaling pathway and prevents cardiac fibrotic remodeling

TGFβ signaling pathway controls tissue fibrotic remodeling, a hallmark in many diseases leading to organ injury and failure. In this study, we address the role of Apilimod, a pharmacological inhibitor of the lipid kinase PIKfyve, in the regulation of cardiac pathological fibrotic remodeling and TGFβ...

Ausführliche Beschreibung