Targeted Genome Mining Reveals the Biosynthetic Gene Clusters of Natural Product CYP51 Inhibitors

Lanosterol 14α-demethylase (CYP51) is an important target in the development of antifungal drugs. The fungal-derived restricticin 1 and related molecules are the only examples of natural products that inhibit CYP51. Here, using colocalizations of genes encoding self-resistant CYP51 as the query, we...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of the American Chemical Society 2021-04, Vol.143 (16), p.6043-6047
Hauptverfasser:	Liu, Nicholas, Abramyan, Elizabeth D, Cheng, Wei, Perlatti, Bruno, Harvey, Colin J.B, Bills, Gerald F, Tang, Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	14-alpha Demethylase Inhibitors - metabolism Antifungal Agents - chemistry Antifungal Agents - metabolism Biological Products - chemistry Biological Products - metabolism Cytochrome P450 Family 51 - genetics Cytochrome P450 Family 51 - metabolism Fungal Proteins - genetics Fungal Proteins - metabolism Fungi - genetics Multigene Family Pyrans - chemistry Pyrans - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!