Fasting Plasma GLP-1 Is Associated With Overweight/Obesity and Cardiometabolic Risk Factors in Children and Adolescents
Abstract Context The importance of fasting glucagon-like peptide-1 (GLP-1) in altered metabolic outcomes has been questioned. Objective This work aimed to assess whether fasting GLP-1 differs in children and adolescents with overweight/obesity compared to a population-based reference, and whether co...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2021-06, Vol.106 (6), p.1718-1727 |
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| creator | Stinson, Sara E Jonsson, Anna E Lund, Morten A V Frithioff-Bøjsøe, Christine Aas Holm, Louise Pedersen, Oluf Ängquist, Lars Sørensen, Thorkild I A Holst, Jens J Christiansen, Michael Holm, Jens-Christian Hartmann, Bolette Hansen, Torben |
| description | Abstract
Context
The importance of fasting glucagon-like peptide-1 (GLP-1) in altered metabolic outcomes has been questioned.
Objective
This work aimed to assess whether fasting GLP-1 differs in children and adolescents with overweight/obesity compared to a population-based reference, and whether concentrations predict cardiometabolic risk (CMR) factors.
Methods
Analyses were based on The Danish Childhood Obesity Data- and Biobank, a cross-sectional study including children and adolescents, aged 6 to 19 years, from an obesity clinic group (n = 1978) and from a population-based group (n = 2334). Fasting concentrations of plasma total GLP-1 and quantitative CMR factors were assessed. The effects of GLP-1 as a predictor of CMR risk outcomes were examined by multiple linear and logistic regression modeling.
Results
The obesity clinic group had higher fasting GLP-1 concentrations (median 3.3 pmol/L; interquartile range, 2.3-4.3 pmol/L) than the population-based group (2.8 pmol/L; interquartile range, 2.1-3.8 pmol/L; P |
| doi_str_mv | 10.1210/clinem/dgab098 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8118577</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A702494002</galeid><oup_id>10.1210/clinem/dgab098</oup_id><sourcerecordid>A702494002</sourcerecordid><originalsourceid>FETCH-LOGICAL-c519t-a8612846dd87841a1b8fae83f72ea790918857df1752b6124be5dc4ca23e4ae13</originalsourceid><addsrcrecordid>eNqFkk1rGzEQhpfS0jhprz0WQS_tYWNpvyRdCsbUacDgUFram5iVZm2lu5IrrRPy7yPXbvpBoOggkJ55hpHeLHvF6DkrGJ3q3jocpmYNLZXiSTZhsqpzziR_mk0oLVguefHtJDuN8ZpSVlV1-Tw7KctaNiWVk-x2AXG0bk2ueogDkIvlVc7IZSSzGL22MKIhX-24IasbDLdo15txumox2vGOgDNkDsFYP-AIre-tJp9s_E4WoEcfIrGOzDe2NwHdT3hmfI9Roxvji-xZB33El8f9LPuy-PB5_jFfri4u57NlrmsmxxxEwwpRNcYILioGrBUdoCg7XiBwSSUTouamY7wu2oRWLdZGVxqKEitAVp5l7w_e7a4d0Ox7B-jVNtgBwp3yYNXfN85u1NrfKMFYMvMkeHsUBP9jh3FUg00j9D049Luoikoyyou6KRP65h_02u-CS-OpQtYNq0veiN_UGnpU1nU-9dV7qZpxmnRV-rZEnT9CpWVwsNo77Gw6f6xABx9jwO5hRkbVPirqEBV1jEoqeP3nyzzgv7KRgHcHwO-2_5PdA9wVyaI</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2956153768</pqid></control><display><type>article</type><title>Fasting Plasma GLP-1 Is Associated With Overweight/Obesity and Cardiometabolic Risk Factors in Children and Adolescents</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Alma/SFX Local Collection</source><source>EZB Electronic Journals Library</source><creator>Stinson, Sara E ; Jonsson, Anna E ; Lund, Morten A V ; Frithioff-Bøjsøe, Christine ; Aas Holm, Louise ; Pedersen, Oluf ; Ängquist, Lars ; Sørensen, Thorkild I A ; Holst, Jens J ; Christiansen, Michael ; Holm, Jens-Christian ; Hartmann, Bolette ; Hansen, Torben</creator><creatorcontrib>Stinson, Sara E ; Jonsson, Anna E ; Lund, Morten A V ; Frithioff-Bøjsøe, Christine ; Aas Holm, Louise ; Pedersen, Oluf ; Ängquist, Lars ; Sørensen, Thorkild I A ; Holst, Jens J ; Christiansen, Michael ; Holm, Jens-Christian ; Hartmann, Bolette ; Hansen, Torben</creatorcontrib><description>Abstract
Context
The importance of fasting glucagon-like peptide-1 (GLP-1) in altered metabolic outcomes has been questioned.
Objective
This work aimed to assess whether fasting GLP-1 differs in children and adolescents with overweight/obesity compared to a population-based reference, and whether concentrations predict cardiometabolic risk (CMR) factors.
Methods
Analyses were based on The Danish Childhood Obesity Data- and Biobank, a cross-sectional study including children and adolescents, aged 6 to 19 years, from an obesity clinic group (n = 1978) and from a population-based group (n = 2334). Fasting concentrations of plasma total GLP-1 and quantitative CMR factors were assessed. The effects of GLP-1 as a predictor of CMR risk outcomes were examined by multiple linear and logistic regression modeling.
Results
The obesity clinic group had higher fasting GLP-1 concentrations (median 3.3 pmol/L; interquartile range, 2.3-4.3 pmol/L) than the population-based group (2.8 pmol/L; interquartile range, 2.1-3.8 pmol/L; P < 2.2E-16). Body mass index SD score (SDS), waist circumference, and total body fat percentage were significant predictors of fasting GLP-1 concentrations in boys and girls. Fasting GLP-1 concentrations were positively associated with homeostasis model assessment of insulin resistance, fasting values of insulin, high-sensitivity C-reactive protein, C-peptide, triglycerides, alanine transaminase (ALT), glycated hemoglobin A1c, and SDS of diastolic and systolic blood pressure. A 1-SD increase in fasting GLP-1 was associated with an increased risk of insulin resistance (odds ratio [OR] 1.59), dyslipidemia (OR 1.16), increased ALT (OR 1.14), hyperglycemia (OR 1.12) and hypertension (OR 1.12).
Conclusion
Overweight/obesity in children and adolescents is associated with increased fasting plasma total GLP-1 concentrations, which was predictive of higher CMR factors.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/clinem/dgab098</identifier><identifier>PMID: 33596309</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Adolescent ; Adolescents ; Alanine transaminase ; Blood pressure ; Body fat ; Body mass index ; Body measurements ; Body weight ; C-reactive protein ; Cardiometabolic Risk Factors ; Child ; Children ; Clinical s ; Cohort Studies ; Comparative analysis ; Cross-Sectional Studies ; Denmark - epidemiology ; Dyslipidemia ; Fasting ; Fasting - blood ; Female ; Glucagon ; Glucagon-like peptide 1 ; Glucagon-Like Peptide 1 - blood ; Glycosylated hemoglobin ; Health aspects ; Hemoglobin ; Homeostasis ; Humans ; Hyperglycemia ; Hypertension ; Insulin resistance ; Liraglutide ; Male ; Obesity ; Obesity in adolescence ; Obesity in children ; Overweight ; Overweight - blood ; Overweight - complications ; Overweight - epidemiology ; Pediatric Obesity - blood ; Pediatric Obesity - complications ; Pediatric Obesity - epidemiology ; Peptides ; Prognosis ; Risk Factors ; Teenagers ; Triglycerides ; Type 2 diabetes ; Young Adult</subject><ispartof>The journal of clinical endocrinology and metabolism, 2021-06, Vol.106 (6), p.1718-1727</ispartof><rights>The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. 2021</rights><rights>The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society.</rights><rights>COPYRIGHT 2021 Oxford University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c519t-a8612846dd87841a1b8fae83f72ea790918857df1752b6124be5dc4ca23e4ae13</citedby><cites>FETCH-LOGICAL-c519t-a8612846dd87841a1b8fae83f72ea790918857df1752b6124be5dc4ca23e4ae13</cites><orcidid>0000-0002-3321-3972 ; 0000-0001-8748-3831 ; 0000-0001-8509-2036 ; 0000-0002-1491-9179 ; 0000-0001-6853-3805</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33596309$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stinson, Sara E</creatorcontrib><creatorcontrib>Jonsson, Anna E</creatorcontrib><creatorcontrib>Lund, Morten A V</creatorcontrib><creatorcontrib>Frithioff-Bøjsøe, Christine</creatorcontrib><creatorcontrib>Aas Holm, Louise</creatorcontrib><creatorcontrib>Pedersen, Oluf</creatorcontrib><creatorcontrib>Ängquist, Lars</creatorcontrib><creatorcontrib>Sørensen, Thorkild I A</creatorcontrib><creatorcontrib>Holst, Jens J</creatorcontrib><creatorcontrib>Christiansen, Michael</creatorcontrib><creatorcontrib>Holm, Jens-Christian</creatorcontrib><creatorcontrib>Hartmann, Bolette</creatorcontrib><creatorcontrib>Hansen, Torben</creatorcontrib><title>Fasting Plasma GLP-1 Is Associated With Overweight/Obesity and Cardiometabolic Risk Factors in Children and Adolescents</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Abstract
Context
The importance of fasting glucagon-like peptide-1 (GLP-1) in altered metabolic outcomes has been questioned.
Objective
This work aimed to assess whether fasting GLP-1 differs in children and adolescents with overweight/obesity compared to a population-based reference, and whether concentrations predict cardiometabolic risk (CMR) factors.
Methods
Analyses were based on The Danish Childhood Obesity Data- and Biobank, a cross-sectional study including children and adolescents, aged 6 to 19 years, from an obesity clinic group (n = 1978) and from a population-based group (n = 2334). Fasting concentrations of plasma total GLP-1 and quantitative CMR factors were assessed. The effects of GLP-1 as a predictor of CMR risk outcomes were examined by multiple linear and logistic regression modeling.
Results
The obesity clinic group had higher fasting GLP-1 concentrations (median 3.3 pmol/L; interquartile range, 2.3-4.3 pmol/L) than the population-based group (2.8 pmol/L; interquartile range, 2.1-3.8 pmol/L; P < 2.2E-16). Body mass index SD score (SDS), waist circumference, and total body fat percentage were significant predictors of fasting GLP-1 concentrations in boys and girls. Fasting GLP-1 concentrations were positively associated with homeostasis model assessment of insulin resistance, fasting values of insulin, high-sensitivity C-reactive protein, C-peptide, triglycerides, alanine transaminase (ALT), glycated hemoglobin A1c, and SDS of diastolic and systolic blood pressure. A 1-SD increase in fasting GLP-1 was associated with an increased risk of insulin resistance (odds ratio [OR] 1.59), dyslipidemia (OR 1.16), increased ALT (OR 1.14), hyperglycemia (OR 1.12) and hypertension (OR 1.12).
Conclusion
Overweight/obesity in children and adolescents is associated with increased fasting plasma total GLP-1 concentrations, which was predictive of higher CMR factors.</description><subject>Adolescent</subject><subject>Adolescents</subject><subject>Alanine transaminase</subject><subject>Blood pressure</subject><subject>Body fat</subject><subject>Body mass index</subject><subject>Body measurements</subject><subject>Body weight</subject><subject>C-reactive protein</subject><subject>Cardiometabolic Risk Factors</subject><subject>Child</subject><subject>Children</subject><subject>Clinical s</subject><subject>Cohort Studies</subject><subject>Comparative analysis</subject><subject>Cross-Sectional Studies</subject><subject>Denmark - epidemiology</subject><subject>Dyslipidemia</subject><subject>Fasting</subject><subject>Fasting - blood</subject><subject>Female</subject><subject>Glucagon</subject><subject>Glucagon-like peptide 1</subject><subject>Glucagon-Like Peptide 1 - blood</subject><subject>Glycosylated hemoglobin</subject><subject>Health aspects</subject><subject>Hemoglobin</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Hyperglycemia</subject><subject>Hypertension</subject><subject>Insulin resistance</subject><subject>Liraglutide</subject><subject>Male</subject><subject>Obesity</subject><subject>Obesity in adolescence</subject><subject>Obesity in children</subject><subject>Overweight</subject><subject>Overweight - blood</subject><subject>Overweight - complications</subject><subject>Overweight - epidemiology</subject><subject>Pediatric Obesity - blood</subject><subject>Pediatric Obesity - complications</subject><subject>Pediatric Obesity - epidemiology</subject><subject>Peptides</subject><subject>Prognosis</subject><subject>Risk Factors</subject><subject>Teenagers</subject><subject>Triglycerides</subject><subject>Type 2 diabetes</subject><subject>Young Adult</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><sourceid>EIF</sourceid><recordid>eNqFkk1rGzEQhpfS0jhprz0WQS_tYWNpvyRdCsbUacDgUFram5iVZm2lu5IrrRPy7yPXbvpBoOggkJ55hpHeLHvF6DkrGJ3q3jocpmYNLZXiSTZhsqpzziR_mk0oLVguefHtJDuN8ZpSVlV1-Tw7KctaNiWVk-x2AXG0bk2ueogDkIvlVc7IZSSzGL22MKIhX-24IasbDLdo15txumox2vGOgDNkDsFYP-AIre-tJp9s_E4WoEcfIrGOzDe2NwHdT3hmfI9Roxvji-xZB33El8f9LPuy-PB5_jFfri4u57NlrmsmxxxEwwpRNcYILioGrBUdoCg7XiBwSSUTouamY7wu2oRWLdZGVxqKEitAVp5l7w_e7a4d0Ox7B-jVNtgBwp3yYNXfN85u1NrfKMFYMvMkeHsUBP9jh3FUg00j9D049Luoikoyyou6KRP65h_02u-CS-OpQtYNq0veiN_UGnpU1nU-9dV7qZpxmnRV-rZEnT9CpWVwsNo77Gw6f6xABx9jwO5hRkbVPirqEBV1jEoqeP3nyzzgv7KRgHcHwO-2_5PdA9wVyaI</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Stinson, Sara E</creator><creator>Jonsson, Anna E</creator><creator>Lund, Morten A V</creator><creator>Frithioff-Bøjsøe, Christine</creator><creator>Aas Holm, Louise</creator><creator>Pedersen, Oluf</creator><creator>Ängquist, Lars</creator><creator>Sørensen, Thorkild I A</creator><creator>Holst, Jens J</creator><creator>Christiansen, Michael</creator><creator>Holm, Jens-Christian</creator><creator>Hartmann, Bolette</creator><creator>Hansen, Torben</creator><general>Oxford University Press</general><scope>TOX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>7TM</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3321-3972</orcidid><orcidid>https://orcid.org/0000-0001-8748-3831</orcidid><orcidid>https://orcid.org/0000-0001-8509-2036</orcidid><orcidid>https://orcid.org/0000-0002-1491-9179</orcidid><orcidid>https://orcid.org/0000-0001-6853-3805</orcidid></search><sort><creationdate>20210601</creationdate><title>Fasting Plasma GLP-1 Is Associated With Overweight/Obesity and Cardiometabolic Risk Factors in Children and Adolescents</title><author>Stinson, Sara E ; Jonsson, Anna E ; Lund, Morten A V ; Frithioff-Bøjsøe, Christine ; Aas Holm, Louise ; Pedersen, Oluf ; Ängquist, Lars ; Sørensen, Thorkild I A ; Holst, Jens J ; Christiansen, Michael ; Holm, Jens-Christian ; Hartmann, Bolette ; Hansen, Torben</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c519t-a8612846dd87841a1b8fae83f72ea790918857df1752b6124be5dc4ca23e4ae13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescent</topic><topic>Adolescents</topic><topic>Alanine transaminase</topic><topic>Blood pressure</topic><topic>Body fat</topic><topic>Body mass index</topic><topic>Body measurements</topic><topic>Body weight</topic><topic>C-reactive protein</topic><topic>Cardiometabolic Risk Factors</topic><topic>Child</topic><topic>Children</topic><topic>Clinical s</topic><topic>Cohort Studies</topic><topic>Comparative analysis</topic><topic>Cross-Sectional Studies</topic><topic>Denmark - epidemiology</topic><topic>Dyslipidemia</topic><topic>Fasting</topic><topic>Fasting - blood</topic><topic>Female</topic><topic>Glucagon</topic><topic>Glucagon-like peptide 1</topic><topic>Glucagon-Like Peptide 1 - blood</topic><topic>Glycosylated hemoglobin</topic><topic>Health aspects</topic><topic>Hemoglobin</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Hyperglycemia</topic><topic>Hypertension</topic><topic>Insulin resistance</topic><topic>Liraglutide</topic><topic>Male</topic><topic>Obesity</topic><topic>Obesity in adolescence</topic><topic>Obesity in children</topic><topic>Overweight</topic><topic>Overweight - blood</topic><topic>Overweight - complications</topic><topic>Overweight - epidemiology</topic><topic>Pediatric Obesity - blood</topic><topic>Pediatric Obesity - complications</topic><topic>Pediatric Obesity - epidemiology</topic><topic>Peptides</topic><topic>Prognosis</topic><topic>Risk Factors</topic><topic>Teenagers</topic><topic>Triglycerides</topic><topic>Type 2 diabetes</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stinson, Sara E</creatorcontrib><creatorcontrib>Jonsson, Anna E</creatorcontrib><creatorcontrib>Lund, Morten A V</creatorcontrib><creatorcontrib>Frithioff-Bøjsøe, Christine</creatorcontrib><creatorcontrib>Aas Holm, Louise</creatorcontrib><creatorcontrib>Pedersen, Oluf</creatorcontrib><creatorcontrib>Ängquist, Lars</creatorcontrib><creatorcontrib>Sørensen, Thorkild I A</creatorcontrib><creatorcontrib>Holst, Jens J</creatorcontrib><creatorcontrib>Christiansen, Michael</creatorcontrib><creatorcontrib>Holm, Jens-Christian</creatorcontrib><creatorcontrib>Hartmann, Bolette</creatorcontrib><creatorcontrib>Hansen, Torben</creatorcontrib><collection>Access via Oxford University Press (Open Access Collection)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stinson, Sara E</au><au>Jonsson, Anna E</au><au>Lund, Morten A V</au><au>Frithioff-Bøjsøe, Christine</au><au>Aas Holm, Louise</au><au>Pedersen, Oluf</au><au>Ängquist, Lars</au><au>Sørensen, Thorkild I A</au><au>Holst, Jens J</au><au>Christiansen, Michael</au><au>Holm, Jens-Christian</au><au>Hartmann, Bolette</au><au>Hansen, Torben</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fasting Plasma GLP-1 Is Associated With Overweight/Obesity and Cardiometabolic Risk Factors in Children and Adolescents</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2021-06-01</date><risdate>2021</risdate><volume>106</volume><issue>6</issue><spage>1718</spage><epage>1727</epage><pages>1718-1727</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><abstract>Abstract
Context
The importance of fasting glucagon-like peptide-1 (GLP-1) in altered metabolic outcomes has been questioned.
Objective
This work aimed to assess whether fasting GLP-1 differs in children and adolescents with overweight/obesity compared to a population-based reference, and whether concentrations predict cardiometabolic risk (CMR) factors.
Methods
Analyses were based on The Danish Childhood Obesity Data- and Biobank, a cross-sectional study including children and adolescents, aged 6 to 19 years, from an obesity clinic group (n = 1978) and from a population-based group (n = 2334). Fasting concentrations of plasma total GLP-1 and quantitative CMR factors were assessed. The effects of GLP-1 as a predictor of CMR risk outcomes were examined by multiple linear and logistic regression modeling.
Results
The obesity clinic group had higher fasting GLP-1 concentrations (median 3.3 pmol/L; interquartile range, 2.3-4.3 pmol/L) than the population-based group (2.8 pmol/L; interquartile range, 2.1-3.8 pmol/L; P < 2.2E-16). Body mass index SD score (SDS), waist circumference, and total body fat percentage were significant predictors of fasting GLP-1 concentrations in boys and girls. Fasting GLP-1 concentrations were positively associated with homeostasis model assessment of insulin resistance, fasting values of insulin, high-sensitivity C-reactive protein, C-peptide, triglycerides, alanine transaminase (ALT), glycated hemoglobin A1c, and SDS of diastolic and systolic blood pressure. A 1-SD increase in fasting GLP-1 was associated with an increased risk of insulin resistance (odds ratio [OR] 1.59), dyslipidemia (OR 1.16), increased ALT (OR 1.14), hyperglycemia (OR 1.12) and hypertension (OR 1.12).
Conclusion
Overweight/obesity in children and adolescents is associated with increased fasting plasma total GLP-1 concentrations, which was predictive of higher CMR factors.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>33596309</pmid><doi>10.1210/clinem/dgab098</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-3321-3972</orcidid><orcidid>https://orcid.org/0000-0001-8748-3831</orcidid><orcidid>https://orcid.org/0000-0001-8509-2036</orcidid><orcidid>https://orcid.org/0000-0002-1491-9179</orcidid><orcidid>https://orcid.org/0000-0001-6853-3805</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | The journal of clinical endocrinology and metabolism, 2021-06, Vol.106 (6), p.1718-1727 |
| issn | 0021-972X 1945-7197 |
| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Adolescent Adolescents Alanine transaminase Blood pressure Body fat Body mass index Body measurements Body weight C-reactive protein Cardiometabolic Risk Factors Child Children Clinical s Cohort Studies Comparative analysis Cross-Sectional Studies Denmark - epidemiology Dyslipidemia Fasting Fasting - blood Female Glucagon Glucagon-like peptide 1 Glucagon-Like Peptide 1 - blood Glycosylated hemoglobin Health aspects Hemoglobin Homeostasis Humans Hyperglycemia Hypertension Insulin resistance Liraglutide Male Obesity Obesity in adolescence Obesity in children Overweight Overweight - blood Overweight - complications Overweight - epidemiology Pediatric Obesity - blood Pediatric Obesity - complications Pediatric Obesity - epidemiology Peptides Prognosis Risk Factors Teenagers Triglycerides Type 2 diabetes Young Adult |
| title | Fasting Plasma GLP-1 Is Associated With Overweight/Obesity and Cardiometabolic Risk Factors in Children and Adolescents |
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