BMI1 enables extensive expansion of functional erythroblasts from human peripheral blood mononuclear cells

Transfusion of red blood cells (RBCs) from ABO-matched but genetically unrelated donors is commonly used for treating anemia and acute blood loss. Increasing demand and insufficient supply for donor RBCs, especially those of universal blood types or free of known and unknown pathogens, has called fo...

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Veröffentlicht in:	Molecular therapy 2021-05, Vol.29 (5), p.1918-1932
Hauptverfasser:	Liu, Senquan, Wu, Mengyao, Lancelot, Moira, Deng, Jiusheng, Gao, Yongxing, Roback, John D., Chen, Tong, Cheng, Linzhao
Format:	Artikel
Sprache:	eng
Schlagworte:	BMI1 enucleation erythroblasts gene editing Original RBC sickle cell disease transfusion
Online-Zugang:	Volltext
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