Noninvasive visualization of electrical conductivity in tissues at the micrometer scale

Noninvasive visualization of electrical conductivity in tissues at the micrometer scale

Despite its importance in regulating cellular or tissue function, electrical conductivity can only be visualized in tissue indirectly as voltage potentials using fluorescent techniques, or directly with radio waves. These either requires invasive procedures like genetic modification or suffers from...

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Veröffentlicht in:Science advances 2021-05, Vol.7 (20)
Hauptverfasser: Huang, Yuanhui, Omar, Murad, Tian, Weili, Lopez-Schier, Hernán, Westmeyer, Gil Gregor, Chmyrov, Andriy, Sergiadis, George, Ntziachristos, Vasilis
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container_issue 20
container_start_page
container_title Science advances
container_volume 7
creator Huang, Yuanhui
Omar, Murad
Tian, Weili
Lopez-Schier, Hernán
Westmeyer, Gil Gregor
Chmyrov, Andriy
Sergiadis, George
Ntziachristos, Vasilis
description Despite its importance in regulating cellular or tissue function, electrical conductivity can only be visualized in tissue indirectly as voltage potentials using fluorescent techniques, or directly with radio waves. These either requires invasive procedures like genetic modification or suffers from limited resolution. Here, we introduce radio-frequency thermoacoustic mesoscopy (RThAM) for the noninvasive imaging of conductivity by exploiting the direct absorption of near-field ultrashort radio-frequency pulses to stimulate the emission of broadband ultrasound waves. Detection of ultrasound rather than radio waves enables micrometer-scale resolutions, over several millimeters of tissue depth. We confirm an imaging resolution of
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subjects Applied Sciences and Engineering
Life Sciences
SciAdv r-articles
title Noninvasive visualization of electrical conductivity in tissues at the micrometer scale
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