Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases
The gut microbiota has a critical role in the maintenance of immune homeostasis. Alterations in the intestinal microbiota and gut microbiota-derived metabolites have been recognized in many immune-related inflammatory disorders. These metabolites can be produced by gut microbiota from dietary compon...
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| Veröffentlicht in: | Cellular & molecular immunology 2021-04, Vol.18 (4), p.866-877 |
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| description | The gut microbiota has a critical role in the maintenance of immune homeostasis. Alterations in the intestinal microbiota and gut microbiota-derived metabolites have been recognized in many immune-related inflammatory disorders. These metabolites can be produced by gut microbiota from dietary components or by the host and can be modified by gut bacteria or synthesized
de novo
by gut bacteria. Gut microbiota-derived metabolites influence a plethora of immune cell responses, including T cells, B cells, dendritic cells, and macrophages. Some of these metabolites are involved in the pathogenesis of immune-related inflammatory diseases, such as inflammatory bowel diseases, diabetes, rheumatoid arthritis, and systemic lupus erythematosus. Here, we review the role of microbiota-derived metabolites in regulating the functions of different immune cells and the pathogenesis of chronic immune-related inflammatory diseases. |
| doi_str_mv | 10.1038/s41423-021-00661-4 |
| format | Article |
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de novo
by gut bacteria. Gut microbiota-derived metabolites influence a plethora of immune cell responses, including T cells, B cells, dendritic cells, and macrophages. Some of these metabolites are involved in the pathogenesis of immune-related inflammatory diseases, such as inflammatory bowel diseases, diabetes, rheumatoid arthritis, and systemic lupus erythematosus. Here, we review the role of microbiota-derived metabolites in regulating the functions of different immune cells and the pathogenesis of chronic immune-related inflammatory diseases.</description><identifier>ISSN: 1672-7681</identifier><identifier>EISSN: 2042-0226</identifier><identifier>DOI: 10.1038/s41423-021-00661-4</identifier><identifier>PMID: 33707689</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/250 ; 631/250/347 ; Animals ; Antibodies ; Arthritis, Rheumatoid - etiology ; Arthritis, Rheumatoid - metabolism ; Arthritis, Rheumatoid - pathology ; Bacteria ; Bacteria - metabolism ; Beta cells ; Biomedical and Life Sciences ; Biomedicine ; Dendritic cells ; Diabetes mellitus ; Digestive system ; Gastrointestinal Microbiome ; Gastrointestinal tract ; Homeostasis ; Humans ; Immune System Diseases - etiology ; Immune System Diseases - metabolism ; Immune System Diseases - pathology ; Immunity ; Immunology ; Inflammatory bowel diseases ; Inflammatory Bowel Diseases - etiology ; Inflammatory Bowel Diseases - metabolism ; Inflammatory Bowel Diseases - pathology ; Inflammatory diseases ; Intestinal microflora ; Intestine ; Lymphocytes T ; Macrophages ; Medical Microbiology ; Metabolites ; Metabolome ; Microbiology ; Microbiota ; Pathogenesis ; Review ; Review Article ; Rheumatoid arthritis ; Systemic lupus erythematosus ; Vaccine</subject><ispartof>Cellular & molecular immunology, 2021-04, Vol.18 (4), p.866-877</ispartof><rights>The Author(s), under exclusive licence to CSI and USTC 2021</rights><rights>The Author(s), under exclusive licence to CSI and USTC 2021.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c523t-c1bd095c63b6ee85692b2bc3ee443ce644c7d606d17e09a92446372f8aedc1733</citedby><cites>FETCH-LOGICAL-c523t-c1bd095c63b6ee85692b2bc3ee443ce644c7d606d17e09a92446372f8aedc1733</cites><orcidid>0000-0003-4167-7395</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115644/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115644/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33707689$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Wenjing</creatorcontrib><creatorcontrib>Cong, Yingzi</creatorcontrib><title>Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases</title><title>Cellular & molecular immunology</title><addtitle>Cell Mol Immunol</addtitle><addtitle>Cell Mol Immunol</addtitle><description>The gut microbiota has a critical role in the maintenance of immune homeostasis. Alterations in the intestinal microbiota and gut microbiota-derived metabolites have been recognized in many immune-related inflammatory disorders. These metabolites can be produced by gut microbiota from dietary components or by the host and can be modified by gut bacteria or synthesized
de novo
by gut bacteria. Gut microbiota-derived metabolites influence a plethora of immune cell responses, including T cells, B cells, dendritic cells, and macrophages. Some of these metabolites are involved in the pathogenesis of immune-related inflammatory diseases, such as inflammatory bowel diseases, diabetes, rheumatoid arthritis, and systemic lupus erythematosus. Here, we review the role of microbiota-derived metabolites in regulating the functions of different immune cells and the pathogenesis of chronic immune-related inflammatory diseases.</description><subject>631/250</subject><subject>631/250/347</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Arthritis, Rheumatoid - etiology</subject><subject>Arthritis, Rheumatoid - metabolism</subject><subject>Arthritis, Rheumatoid - pathology</subject><subject>Bacteria</subject><subject>Bacteria - metabolism</subject><subject>Beta cells</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Dendritic cells</subject><subject>Diabetes mellitus</subject><subject>Digestive system</subject><subject>Gastrointestinal Microbiome</subject><subject>Gastrointestinal tract</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Immune System Diseases - etiology</subject><subject>Immune System Diseases - metabolism</subject><subject>Immune System Diseases - pathology</subject><subject>Immunity</subject><subject>Immunology</subject><subject>Inflammatory bowel diseases</subject><subject>Inflammatory Bowel Diseases - etiology</subject><subject>Inflammatory Bowel Diseases - metabolism</subject><subject>Inflammatory Bowel Diseases - pathology</subject><subject>Inflammatory diseases</subject><subject>Intestinal microflora</subject><subject>Intestine</subject><subject>Lymphocytes T</subject><subject>Macrophages</subject><subject>Medical Microbiology</subject><subject>Metabolites</subject><subject>Metabolome</subject><subject>Microbiology</subject><subject>Microbiota</subject><subject>Pathogenesis</subject><subject>Review</subject><subject>Review Article</subject><subject>Rheumatoid arthritis</subject><subject>Systemic lupus erythematosus</subject><subject>Vaccine</subject><issn>1672-7681</issn><issn>2042-0226</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kUtv1DAUhS1ERacDf4AFisSGjalfsZMNEqqgRarEpqwtx7mZcRXbg-2M1H9fT2cojwUrS-d-PvdxEHpLyUdKeHeZBRWMY8IoJkRKisULtGJEsCox-RKtqFQMK9nRc3SR8z0hbSeUeIXOOVek6v0K7a-X0nhnUxxcLAaPkNwexsZDMUOcXYHcuNCULTQJNstsiouhiVOzjbk0zvslHCp5F0OuqAnjScQJKlydXJhm470pMT00o8tgKvganU1mzvDm9K7Rj69f7q5u8O33629Xn2-xbRkv2NJhJH1rJR8kQNfKng1ssBxACG5BCmHVKIkcqQLSm54JIbliU2dgtFRxvkafjr67ZfBVg1CSmfUuOW_Sg47G6b8rwW31Ju51R2lb7avBh5NBij8XyEV7ly3MswkQl6xZSyiTTNa-a_T-H_Q-LinU9Q6U6kjbS1opdqTqyXNOMD0PQ4k-xKqPseoaq36KVR-mePfnGs9ffuVYAX4Eci2FDaTfvf9j-wh9rLDD</recordid><startdate>20210401</startdate><enddate>20210401</enddate><creator>Yang, Wenjing</creator><creator>Cong, Yingzi</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4167-7395</orcidid></search><sort><creationdate>20210401</creationdate><title>Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases</title><author>Yang, Wenjing ; Cong, Yingzi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c523t-c1bd095c63b6ee85692b2bc3ee443ce644c7d606d17e09a92446372f8aedc1733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>631/250</topic><topic>631/250/347</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Arthritis, Rheumatoid - etiology</topic><topic>Arthritis, Rheumatoid - metabolism</topic><topic>Arthritis, Rheumatoid - pathology</topic><topic>Bacteria</topic><topic>Bacteria - metabolism</topic><topic>Beta cells</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Dendritic cells</topic><topic>Diabetes mellitus</topic><topic>Digestive system</topic><topic>Gastrointestinal Microbiome</topic><topic>Gastrointestinal tract</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Immune System Diseases - etiology</topic><topic>Immune System Diseases - metabolism</topic><topic>Immune System Diseases - pathology</topic><topic>Immunity</topic><topic>Immunology</topic><topic>Inflammatory bowel diseases</topic><topic>Inflammatory Bowel Diseases - etiology</topic><topic>Inflammatory Bowel Diseases - metabolism</topic><topic>Inflammatory Bowel Diseases - pathology</topic><topic>Inflammatory diseases</topic><topic>Intestinal microflora</topic><topic>Intestine</topic><topic>Lymphocytes T</topic><topic>Macrophages</topic><topic>Medical Microbiology</topic><topic>Metabolites</topic><topic>Metabolome</topic><topic>Microbiology</topic><topic>Microbiota</topic><topic>Pathogenesis</topic><topic>Review</topic><topic>Review Article</topic><topic>Rheumatoid arthritis</topic><topic>Systemic lupus erythematosus</topic><topic>Vaccine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Wenjing</creatorcontrib><creatorcontrib>Cong, Yingzi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cellular & molecular immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Wenjing</au><au>Cong, Yingzi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases</atitle><jtitle>Cellular & molecular immunology</jtitle><stitle>Cell Mol Immunol</stitle><addtitle>Cell Mol Immunol</addtitle><date>2021-04-01</date><risdate>2021</risdate><volume>18</volume><issue>4</issue><spage>866</spage><epage>877</epage><pages>866-877</pages><issn>1672-7681</issn><eissn>2042-0226</eissn><abstract>The gut microbiota has a critical role in the maintenance of immune homeostasis. Alterations in the intestinal microbiota and gut microbiota-derived metabolites have been recognized in many immune-related inflammatory disorders. These metabolites can be produced by gut microbiota from dietary components or by the host and can be modified by gut bacteria or synthesized
de novo
by gut bacteria. Gut microbiota-derived metabolites influence a plethora of immune cell responses, including T cells, B cells, dendritic cells, and macrophages. Some of these metabolites are involved in the pathogenesis of immune-related inflammatory diseases, such as inflammatory bowel diseases, diabetes, rheumatoid arthritis, and systemic lupus erythematosus. Here, we review the role of microbiota-derived metabolites in regulating the functions of different immune cells and the pathogenesis of chronic immune-related inflammatory diseases.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>33707689</pmid><doi>10.1038/s41423-021-00661-4</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-4167-7395</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Cellular & molecular immunology, 2021-04, Vol.18 (4), p.866-877 |
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| subjects | 631/250 631/250/347 Animals Antibodies Arthritis, Rheumatoid - etiology Arthritis, Rheumatoid - metabolism Arthritis, Rheumatoid - pathology Bacteria Bacteria - metabolism Beta cells Biomedical and Life Sciences Biomedicine Dendritic cells Diabetes mellitus Digestive system Gastrointestinal Microbiome Gastrointestinal tract Homeostasis Humans Immune System Diseases - etiology Immune System Diseases - metabolism Immune System Diseases - pathology Immunity Immunology Inflammatory bowel diseases Inflammatory Bowel Diseases - etiology Inflammatory Bowel Diseases - metabolism Inflammatory Bowel Diseases - pathology Inflammatory diseases Intestinal microflora Intestine Lymphocytes T Macrophages Medical Microbiology Metabolites Metabolome Microbiology Microbiota Pathogenesis Review Review Article Rheumatoid arthritis Systemic lupus erythematosus Vaccine |
| title | Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases |
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