Comorbid anxiety-like behavior in a rat model of colitis is mediated by an upregulation of corticolimbic fatty acid amide hydrolase

Peripheral inflammatory conditions, including those localized to the gastrointestinal tract, are highly comorbid with psychiatric disorders such as anxiety and depression. These behavioral symptoms are poorly managed by conventional treatments for inflammatory diseases and contribute to quality of l...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2021-04, Vol.46 (5), p.992-1003
Hauptverfasser:	Vecchiarelli, Haley A, Morena, Maria, Keenan, Catherine M, Chiang, Vincent, Tan, Kaitlyn, Qiao, Min, Leitl, Kira, Santori, Alessia, Pittman, Quentin J, Sharkey, Keith A, Hill, Matthew N
Format:	Artikel
Sprache:	eng
Schlagworte:	Amidohydrolases - metabolism Anandamide Animals Anxiety Behavior Colitis Comorbidity Corticosterone Corticotropin-releasing hormone Emotional behavior Endocannabinoids Fatty acids Fatty-acid amide hydrolase Gastrointestinal tract Glucocorticoids Hydrolase Inflammation Inflammatory bowel disease Inflammatory diseases Male Mental disorders Polyunsaturated Alkamides Quality of Life Rats Rats, Sprague-Dawley Sulfonic acid Up-Regulation
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