NRF2-GPX4/SOD2 axis imparts resistance to EGFR-tyrosine kinase inhibitors in non-small-cell lung cancer cells

Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) have achieved satisfactory clinical effects in the therapy of non-small cell lung cancer (NSCLC), but acquired resistance limits their clinical application. NRF2 has been shown to enhance the resistance to apoptosis induced by r...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Acta pharmacologica Sinica 2021-04, Vol.42 (4), p.613-623
Hauptverfasser:	Ma, Chun-shuang, Lv, Qian-ming, Zhang, Ke-ren, Tang, Ya-bin, Zhang, Yu-fei, Shen, Ying, Lei, Hui-min, Zhu, Liang
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biomedical and Life Sciences Biomedicine Carbolines - pharmacology Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - metabolism Cell Line, Tumor Chemotherapy Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - physiology Epidermal growth factor Epidermal growth factor receptors Epithelial-Mesenchymal Transition - drug effects Epithelial-Mesenchymal Transition - physiology ErbB Receptors - antagonists & inhibitors Erlotinib Hydrochloride - pharmacology Gefitinib - pharmacology Gene Knockdown Techniques Humans Immunology Internal Medicine Kinases Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - metabolism Medical Microbiology NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Non-small cell lung carcinoma NRF2 protein Pharmacology/Toxicology Phospholipid Hydroperoxide Glutathione Peroxidase - metabolism Protein Kinase Inhibitors - pharmacology Radiation therapy RNA, Small Interfering - pharmacology Small cell lung carcinoma Superoxide dismutase Superoxide Dismutase - genetics Superoxide Dismutase - metabolism Tyrosine kinase inhibitors Up-Regulation - physiology Vaccine
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!