Engineered human myocardium with local release of angiogenic proteins improves vascularization and cardiac function in injured rat hearts

Heart regeneration after myocardial infarction requires new cardiomyocytes and a supportive vascular network. Here, we evaluate the efficacy of localized delivery of angiogenic factors from biomaterials within the implanted muscle tissue to guide growth of a more dense, organized, and perfused vascu...

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Veröffentlicht in:	Biomaterials 2020-08, Vol.251, p.120033-120033, Article 120033
Hauptverfasser:	Munarin, Fabiola, Kant, Rajeev J., Rupert, Cassady E., Khoo, Amelia, Coulombe, Kareen L.K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alginate microspheres Angiogenesis hiPSC-derived cardiomyocytes Local growth factor release Myocardial regeneration Tissue engineering
Online-Zugang:	Volltext
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