Role of IL-36γ/IL-36R Signaling in Corneal Innate Defense Against Candida albicans Keratitis

Interleukin (IL)-36 cytokines have been shown to play either beneficial or detrimental roles in the infection of mucosal tissues in a pathogen-dependent manner, but their involvement in fungal keratitis remains elusive. We herein investigated their expression and function in mediating corneal innate...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2021-05, Vol.62 (6), p.10-10
Hauptverfasser:	Dai, Chenyang, Me, Rao, Gao, Nan, Su, Guanyu, Wu, Xinyi, Yu, Fu-Shin X
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Candida albicans Cornea Corneal Ulcer - immunology Corneal Ulcer - microbiology Corneal Ulcer - prevention & control Dendritic Cells - immunology Enzyme-Linked Immunosorbent Assay Eye Infections, Fungal - immunology Eye Infections, Fungal - microbiology Eye Infections, Fungal - prevention & control Gene Expression Regulation - physiology Immunity, Innate - physiology Interleukin-1 - physiology Keratitis - immunology Keratitis - microbiology Keratitis - prevention & control Macrophages - immunology Mice Mice, Inbred C57BL Mice, Knockout Real-Time Polymerase Chain Reaction Receptors, Interleukin-1 - physiology Signal Transduction - physiology
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