Photoreceptor cells and RPE contribute to the development of diabetic retinopathy
Diabetic retinopathy (DR) is a leading cause of blindness. It has long been regarded as vascular disease, but work in the past years has shown abnormalities also in the neural retina. Unfortunately, research on the vascular and neural abnormalities have remained largely separate, instead of being in...
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Veröffentlicht in: | Progress in retinal and eye research 2021-07, Vol.83, p.100919-100919, Article 100919 |
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description | Diabetic retinopathy (DR) is a leading cause of blindness. It has long been regarded as vascular disease, but work in the past years has shown abnormalities also in the neural retina. Unfortunately, research on the vascular and neural abnormalities have remained largely separate, instead of being integrated into a comprehensive view of DR that includes both the neural and vascular components. Recent evidence suggests that the most predominant neural cell in the retina (photoreceptors) and the adjacent retinal pigment epithelium (RPE) play an important role in the development of vascular lesions characteristic of DR. This review summarizes evidence that the outer retina is altered in diabetes, and that photoreceptors and RPE contribute to retinal vascular alterations in the early stages of the retinopathy. The possible molecular mechanisms by which cells of the outer retina might contribute to retinal vascular damage in diabetes also are discussed. Diabetes-induced alterations in the outer retina represent a novel therapeutic target to inhibit DR. |
doi_str_mv | 10.1016/j.preteyeres.2020.100919 |
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It has long been regarded as vascular disease, but work in the past years has shown abnormalities also in the neural retina. Unfortunately, research on the vascular and neural abnormalities have remained largely separate, instead of being integrated into a comprehensive view of DR that includes both the neural and vascular components. Recent evidence suggests that the most predominant neural cell in the retina (photoreceptors) and the adjacent retinal pigment epithelium (RPE) play an important role in the development of vascular lesions characteristic of DR. This review summarizes evidence that the outer retina is altered in diabetes, and that photoreceptors and RPE contribute to retinal vascular alterations in the early stages of the retinopathy. The possible molecular mechanisms by which cells of the outer retina might contribute to retinal vascular damage in diabetes also are discussed. Diabetes-induced alterations in the outer retina represent a novel therapeutic target to inhibit DR.</description><identifier>ISSN: 1350-9462</identifier><identifier>EISSN: 1873-1635</identifier><identifier>DOI: 10.1016/j.preteyeres.2020.100919</identifier><identifier>PMID: 33188897</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Diabetes ; Diabetic retinopathy ; Outer retina ; Photoreceptors ; Phototransduction ; RPE ; Vasculature ; Visual cycle</subject><ispartof>Progress in retinal and eye research, 2021-07, Vol.83, p.100919-100919, Article 100919</ispartof><rights>2020 Elsevier Ltd</rights><rights>Copyright © 2020 Elsevier Ltd. 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It has long been regarded as vascular disease, but work in the past years has shown abnormalities also in the neural retina. Unfortunately, research on the vascular and neural abnormalities have remained largely separate, instead of being integrated into a comprehensive view of DR that includes both the neural and vascular components. Recent evidence suggests that the most predominant neural cell in the retina (photoreceptors) and the adjacent retinal pigment epithelium (RPE) play an important role in the development of vascular lesions characteristic of DR. This review summarizes evidence that the outer retina is altered in diabetes, and that photoreceptors and RPE contribute to retinal vascular alterations in the early stages of the retinopathy. The possible molecular mechanisms by which cells of the outer retina might contribute to retinal vascular damage in diabetes also are discussed. Diabetes-induced alterations in the outer retina represent a novel therapeutic target to inhibit DR.</description><subject>Diabetes</subject><subject>Diabetic retinopathy</subject><subject>Outer retina</subject><subject>Photoreceptors</subject><subject>Phototransduction</subject><subject>RPE</subject><subject>Vasculature</subject><subject>Visual cycle</subject><issn>1350-9462</issn><issn>1873-1635</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqFkUlPwzAQhS0Eomx_AfnIJcVLFvuCBKgsEhKL4Gw5zoS6SuNgu5X673FVKHDiNJbnzczT-xDClIwpoeX5bDx4iLACD2HMCFt_E0nlDjqgouIZLXmxm968IJnMSzZChyHMCCElkcU-GnFOhRCyOkDPT1MXnQcDQyrYQNcFrPsGvzxNsHF99LZeRMDR4TgF3MASOjfMoY_YtbixuoZoDU5ubO8GHaerY7TX6i7AyVc9Qm83k9fru-zh8fb--vIhM3klY1azKidaAxQth5zndcFNzkBoXfGGClmbmlOpBbRgJOMaDJecmIq2tSw0A36ELjZ7h0U9h8YkS153avB2rv1KOW3V305vp-rdLZWglHNG0oKzrwXefSwgRDW3YR2A7sEtgmJ5SaqSpKiSVGykxrsQPLTbM5SoNRE1Uz9E1JqI2hBJo6e_bW4HvxEkwdVGACmspQWvgrHQG2hswhJV4-z_Vz4B_QilOw</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Tonade, Deoye</creator><creator>Kern, Timothy S.</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20210701</creationdate><title>Photoreceptor cells and RPE contribute to the development of diabetic retinopathy</title><author>Tonade, Deoye ; Kern, Timothy S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-b2740aaee5f3e434b53c42e8aa73d189bcb319a8efec923aec3930c71fb95a2e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Diabetes</topic><topic>Diabetic retinopathy</topic><topic>Outer retina</topic><topic>Photoreceptors</topic><topic>Phototransduction</topic><topic>RPE</topic><topic>Vasculature</topic><topic>Visual cycle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tonade, Deoye</creatorcontrib><creatorcontrib>Kern, Timothy S.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Progress in retinal and eye research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tonade, Deoye</au><au>Kern, Timothy S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Photoreceptor cells and RPE contribute to the development of diabetic retinopathy</atitle><jtitle>Progress in retinal and eye research</jtitle><addtitle>Prog Retin Eye Res</addtitle><date>2021-07-01</date><risdate>2021</risdate><volume>83</volume><spage>100919</spage><epage>100919</epage><pages>100919-100919</pages><artnum>100919</artnum><issn>1350-9462</issn><eissn>1873-1635</eissn><abstract>Diabetic retinopathy (DR) is a leading cause of blindness. It has long been regarded as vascular disease, but work in the past years has shown abnormalities also in the neural retina. Unfortunately, research on the vascular and neural abnormalities have remained largely separate, instead of being integrated into a comprehensive view of DR that includes both the neural and vascular components. Recent evidence suggests that the most predominant neural cell in the retina (photoreceptors) and the adjacent retinal pigment epithelium (RPE) play an important role in the development of vascular lesions characteristic of DR. This review summarizes evidence that the outer retina is altered in diabetes, and that photoreceptors and RPE contribute to retinal vascular alterations in the early stages of the retinopathy. The possible molecular mechanisms by which cells of the outer retina might contribute to retinal vascular damage in diabetes also are discussed. 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subjects | Diabetes Diabetic retinopathy Outer retina Photoreceptors Phototransduction RPE Vasculature Visual cycle |
title | Photoreceptor cells and RPE contribute to the development of diabetic retinopathy |
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