Lifestyle Risk Score: handling missingness of individual lifestyle components in meta-analysis of gene-by-lifestyle interactions

Recent studies consider lifestyle risk score (LRS), an aggregation of multiple lifestyle exposures, in identifying association of gene-lifestyle interaction with disease traits. However, not all cohorts have data on all lifestyle factors, leading to increased heterogeneity in the environmental expos...

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Veröffentlicht in:	European journal of human genetics : EJHG 2021-05, Vol.29 (5), p.839-850
Hauptverfasser:	Xu, Hanfei, Schwander, Karen, Brown, Michael R, Wang, Wenyi, Waken, R J, Boerwinkle, Eric, Cupples, L Adrienne, de Las Fuentes, Lisa, van Heemst, Diana, Osazuwa-Peters, Oyomoare, de Vries, Paul S, van Dijk, Ko Willems, Sung, Yun Ju, Zhang, Xiaoyu, Morrison, Alanna C, Rao, D C, Noordam, Raymond, Liu, Ching-Ti
Format:	Artikel
Sprache:	eng
Schlagworte:	Cardiometabolic Risk Factors Gene-Environment Interaction Genome-Wide Association Study - methods Genome-Wide Association Study - standards Genomes Healthy Lifestyle Humans Hypertension - epidemiology Hypertension - genetics Lifestyles Meta-analysis Obesity - epidemiology Obesity - genetics
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