Activated protein C has a regulatory role in factor VIII function

Mechanisms thought to regulate activated factor VIII (FVIIIa) cofactor function include A2-domain dissociation and activated protein C (APC) cleavage. Unlike A2-domain dissociation, there is no known phenotype associated with altered APC cleavage of FVIII, and biochemical studies have suggested APC...

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Veröffentlicht in:	Blood 2021-05, Vol.137 (18), p.2532-2543
Hauptverfasser:	Wilhelm, Amelia R., Parsons, Nicole A., Samelson-Jones, Benjamin J., Davidson, Robert J., Esmon, Charles T., Camire, Rodney M., George, Lindsey A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Thrombosis and Hemostasis
Online-Zugang:	Volltext
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