Effects of Aliskiren‐Based Therapy on Ambulatory Blood Pressure Profile, Central Hemodynamics, and Arterial Stiffness in Nondiabetic Mild to Moderate Hypertensive Patients
J Clin Hypertens (Greenwich). 2012;00:000–000. ©2012 Wiley Periodicals, Inc. Aliskiren is a direct renin inhibitor that exerts its effect at the rate‐limiting step of the renin‐angiotensin system. This study was performed to examine the beneficial effects of aliskiren‐based antihypertensive therapy...
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| Veröffentlicht in: | The journal of clinical hypertension (Greenwich, Conn.) Conn.), 2012-08, Vol.14 (8), p.522-529 |
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| creator | Kanaoka, Tomohiko Tamura, Kouichi Ohsawa, Masato Wakui, Hiromichi Maeda, Akinobu Dejima, Toru Azushima, Kengo Haku, Sona Mitsuhashi, Hiroshi Yanagi, Mai Oshikawa, Jin Uneda, Kazushi Aoki, Kazutaka Fujikawa, Tetsuya Toya, Yoshiyuki Uchino, Kazuaki Umemura, Satoshi |
| description | J Clin Hypertens (Greenwich). 2012;00:000–000. ©2012 Wiley Periodicals, Inc.
Aliskiren is a direct renin inhibitor that exerts its effect at the rate‐limiting step of the renin‐angiotensin system. This study was performed to examine the beneficial effects of aliskiren‐based antihypertensive therapy on the ambulatory blood pressure (BP) profile, central hemodybamics, and arterial stiffness in untreated Japanese patients with mild to moderate hypertension. Twenty‐one Japanese nondiabetic patients with untreated mild to moderate essential hypertension were initially given aliskiren once daily at 150 mg, and the dose was titrated up to 300 mg as needed. After 12 weeks of aliskiren‐based therapy, the clinic, ambulatory, and central BP values as well as brachial‐ankle pulse wave velocity (baPWV) were all significantly decreased compared with baseline (clinic systolic BP, 151±11 mm Hg vs 132±11 mm Hg; clinic diastolic BP, 91±13 mm Hg vs 82±9 mm Hg; 24‐hour systolic BP, 144±12 mm Hg vs 133±11 mm Hg; 24‐hour diastolic BP, 88±8 mm Hg vs 81±9 mm Hg; central BP, 162±16 mm Hg vs 148±14 mm Hg; baPWV, 1625±245 cm/s vs 1495±199 cm/s; P |
| doi_str_mv | 10.1111/j.1751-7176.2012.00640.x |
| format | Article |
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Aliskiren is a direct renin inhibitor that exerts its effect at the rate‐limiting step of the renin‐angiotensin system. This study was performed to examine the beneficial effects of aliskiren‐based antihypertensive therapy on the ambulatory blood pressure (BP) profile, central hemodybamics, and arterial stiffness in untreated Japanese patients with mild to moderate hypertension. Twenty‐one Japanese nondiabetic patients with untreated mild to moderate essential hypertension were initially given aliskiren once daily at 150 mg, and the dose was titrated up to 300 mg as needed. After 12 weeks of aliskiren‐based therapy, the clinic, ambulatory, and central BP values as well as brachial‐ankle pulse wave velocity (baPWV) were all significantly decreased compared with baseline (clinic systolic BP, 151±11 mm Hg vs 132±11 mm Hg; clinic diastolic BP, 91±13 mm Hg vs 82±9 mm Hg; 24‐hour systolic BP, 144±12 mm Hg vs 133±11 mm Hg; 24‐hour diastolic BP, 88±8 mm Hg vs 81±9 mm Hg; central BP, 162±16 mm Hg vs 148±14 mm Hg; baPWV, 1625±245 cm/s vs 1495±199 cm/s; P<.05). These results show that aliskiren, as a first‐line regimen, improves the ambulatory BP profile and may have protective vascular effects in Japanese nondiabetic patients with untreated mild to moderate essential hypertension.</description><identifier>ISSN: 1524-6175</identifier><identifier>EISSN: 1751-7176</identifier><identifier>DOI: 10.1111/j.1751-7176.2012.00640.x</identifier><identifier>PMID: 22863160</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Aged ; Amides - pharmacology ; Amides - therapeutic use ; Antihypertensive Agents - pharmacology ; Antihypertensive Agents - therapeutic use ; Blood Pressure - drug effects ; Blood Pressure - physiology ; Blood Pressure Monitoring, Ambulatory ; Dose-Response Relationship, Drug ; Female ; Fumarates - pharmacology ; Fumarates - therapeutic use ; Hemodynamics - drug effects ; Hemodynamics - physiology ; Humans ; Hypertension - drug therapy ; Hypertension - ethnology ; Hypertension - physiopathology ; Japan ; Male ; Middle Aged ; Original Paper ; Original Papers ; Prospective Studies ; Renin-Angiotensin System - drug effects ; Renin-Angiotensin System - physiology ; Retrospective Studies ; Severity of Illness Index ; Treatment Outcome ; Vascular Stiffness - drug effects ; Vascular Stiffness - physiology</subject><ispartof>The journal of clinical hypertension (Greenwich, Conn.), 2012-08, Vol.14 (8), p.522-529</ispartof><rights>2012 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6790-12409bbda2d4d789b9f16361adcdbe4a961e359e293a0a33d61ef23b4a4ec65d3</citedby><cites>FETCH-LOGICAL-c6790-12409bbda2d4d789b9f16361adcdbe4a961e359e293a0a33d61ef23b4a4ec65d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8108820/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8108820/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,1427,27903,27904,45553,45554,46387,46811,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22863160$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kanaoka, Tomohiko</creatorcontrib><creatorcontrib>Tamura, Kouichi</creatorcontrib><creatorcontrib>Ohsawa, Masato</creatorcontrib><creatorcontrib>Wakui, Hiromichi</creatorcontrib><creatorcontrib>Maeda, Akinobu</creatorcontrib><creatorcontrib>Dejima, Toru</creatorcontrib><creatorcontrib>Azushima, Kengo</creatorcontrib><creatorcontrib>Haku, Sona</creatorcontrib><creatorcontrib>Mitsuhashi, Hiroshi</creatorcontrib><creatorcontrib>Yanagi, Mai</creatorcontrib><creatorcontrib>Oshikawa, Jin</creatorcontrib><creatorcontrib>Uneda, Kazushi</creatorcontrib><creatorcontrib>Aoki, Kazutaka</creatorcontrib><creatorcontrib>Fujikawa, Tetsuya</creatorcontrib><creatorcontrib>Toya, Yoshiyuki</creatorcontrib><creatorcontrib>Uchino, Kazuaki</creatorcontrib><creatorcontrib>Umemura, Satoshi</creatorcontrib><title>Effects of Aliskiren‐Based Therapy on Ambulatory Blood Pressure Profile, Central Hemodynamics, and Arterial Stiffness in Nondiabetic Mild to Moderate Hypertensive Patients</title><title>The journal of clinical hypertension (Greenwich, Conn.)</title><addtitle>J Clin Hypertens (Greenwich)</addtitle><description>J Clin Hypertens (Greenwich). 2012;00:000–000. ©2012 Wiley Periodicals, Inc.
Aliskiren is a direct renin inhibitor that exerts its effect at the rate‐limiting step of the renin‐angiotensin system. This study was performed to examine the beneficial effects of aliskiren‐based antihypertensive therapy on the ambulatory blood pressure (BP) profile, central hemodybamics, and arterial stiffness in untreated Japanese patients with mild to moderate hypertension. Twenty‐one Japanese nondiabetic patients with untreated mild to moderate essential hypertension were initially given aliskiren once daily at 150 mg, and the dose was titrated up to 300 mg as needed. After 12 weeks of aliskiren‐based therapy, the clinic, ambulatory, and central BP values as well as brachial‐ankle pulse wave velocity (baPWV) were all significantly decreased compared with baseline (clinic systolic BP, 151±11 mm Hg vs 132±11 mm Hg; clinic diastolic BP, 91±13 mm Hg vs 82±9 mm Hg; 24‐hour systolic BP, 144±12 mm Hg vs 133±11 mm Hg; 24‐hour diastolic BP, 88±8 mm Hg vs 81±9 mm Hg; central BP, 162±16 mm Hg vs 148±14 mm Hg; baPWV, 1625±245 cm/s vs 1495±199 cm/s; P<.05). These results show that aliskiren, as a first‐line regimen, improves the ambulatory BP profile and may have protective vascular effects in Japanese nondiabetic patients with untreated mild to moderate essential hypertension.</description><subject>Aged</subject><subject>Amides - pharmacology</subject><subject>Amides - therapeutic use</subject><subject>Antihypertensive Agents - pharmacology</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>Blood Pressure - drug effects</subject><subject>Blood Pressure - physiology</subject><subject>Blood Pressure Monitoring, Ambulatory</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Fumarates - pharmacology</subject><subject>Fumarates - therapeutic use</subject><subject>Hemodynamics - drug effects</subject><subject>Hemodynamics - physiology</subject><subject>Humans</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - ethnology</subject><subject>Hypertension - physiopathology</subject><subject>Japan</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original Paper</subject><subject>Original Papers</subject><subject>Prospective Studies</subject><subject>Renin-Angiotensin System - drug effects</subject><subject>Renin-Angiotensin System - physiology</subject><subject>Retrospective Studies</subject><subject>Severity of Illness Index</subject><subject>Treatment Outcome</subject><subject>Vascular Stiffness - drug effects</subject><subject>Vascular Stiffness - physiology</subject><issn>1524-6175</issn><issn>1751-7176</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUV1u1DAYtBCIlsIVkA_QBP8kTiIhpO2qsKAWkCjPlhN_pl4Se2V7S_PGEXqRXoqT4GVhBW_4xWPPNzOyByFMSUnzerEuaVPToqGNKBmhrCREVKS8fYCOD8TDjGtWFSLfHKEnMa4JqTnvyGN0xFgrOBXkGN2fGwNDitgbvBht_GoDuB_f785UBI2vriGozYy9w4up344q-TDjs9F7jT8GiHEbIANv7AineAkuBTXiFUxez05NdoinWDmNFyFBsJn6lKwxLguxdfi9d9qqHpId8KUdNU4eX3qdIxPg1byBrHLR3uQIlWw2j0_RI6PGCM9-7yfo8-vzq-WquPjw5u1ycVEMoulIQVlFur7XiulKN23Xd4YKLqjSg-6hUp2gwOsOWMcVUZzrfDaM95WqYBC15ifo1d53s-0n0MP-YXIT7KTCLL2y8l_G2Wv5xd_IlpK2ZSQbtHuDIfgYA5iDlhK5q1Cu5a4puWtK7iqUvyqUt1n6_O_sg_BPZ3ng5X7gW_71-b-N5bvlKgP-E6wWsHc</recordid><startdate>201208</startdate><enddate>201208</enddate><creator>Kanaoka, Tomohiko</creator><creator>Tamura, Kouichi</creator><creator>Ohsawa, Masato</creator><creator>Wakui, Hiromichi</creator><creator>Maeda, Akinobu</creator><creator>Dejima, Toru</creator><creator>Azushima, Kengo</creator><creator>Haku, Sona</creator><creator>Mitsuhashi, Hiroshi</creator><creator>Yanagi, Mai</creator><creator>Oshikawa, Jin</creator><creator>Uneda, Kazushi</creator><creator>Aoki, Kazutaka</creator><creator>Fujikawa, Tetsuya</creator><creator>Toya, Yoshiyuki</creator><creator>Uchino, Kazuaki</creator><creator>Umemura, Satoshi</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>201208</creationdate><title>Effects of Aliskiren‐Based Therapy on Ambulatory Blood Pressure Profile, Central Hemodynamics, and Arterial Stiffness in Nondiabetic Mild to Moderate Hypertensive Patients</title><author>Kanaoka, Tomohiko ; Tamura, Kouichi ; Ohsawa, Masato ; Wakui, Hiromichi ; Maeda, Akinobu ; Dejima, Toru ; Azushima, Kengo ; Haku, Sona ; Mitsuhashi, Hiroshi ; Yanagi, Mai ; Oshikawa, Jin ; Uneda, Kazushi ; Aoki, Kazutaka ; Fujikawa, Tetsuya ; Toya, Yoshiyuki ; Uchino, Kazuaki ; Umemura, Satoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6790-12409bbda2d4d789b9f16361adcdbe4a961e359e293a0a33d61ef23b4a4ec65d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Amides - pharmacology</topic><topic>Amides - therapeutic use</topic><topic>Antihypertensive Agents - pharmacology</topic><topic>Antihypertensive Agents - therapeutic use</topic><topic>Blood Pressure - drug effects</topic><topic>Blood Pressure - physiology</topic><topic>Blood Pressure Monitoring, Ambulatory</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Fumarates - pharmacology</topic><topic>Fumarates - therapeutic use</topic><topic>Hemodynamics - drug effects</topic><topic>Hemodynamics - physiology</topic><topic>Humans</topic><topic>Hypertension - drug therapy</topic><topic>Hypertension - ethnology</topic><topic>Hypertension - physiopathology</topic><topic>Japan</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Original Paper</topic><topic>Original Papers</topic><topic>Prospective Studies</topic><topic>Renin-Angiotensin System - drug effects</topic><topic>Renin-Angiotensin System - physiology</topic><topic>Retrospective Studies</topic><topic>Severity of Illness Index</topic><topic>Treatment Outcome</topic><topic>Vascular Stiffness - drug effects</topic><topic>Vascular Stiffness - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kanaoka, Tomohiko</creatorcontrib><creatorcontrib>Tamura, Kouichi</creatorcontrib><creatorcontrib>Ohsawa, Masato</creatorcontrib><creatorcontrib>Wakui, Hiromichi</creatorcontrib><creatorcontrib>Maeda, Akinobu</creatorcontrib><creatorcontrib>Dejima, Toru</creatorcontrib><creatorcontrib>Azushima, Kengo</creatorcontrib><creatorcontrib>Haku, Sona</creatorcontrib><creatorcontrib>Mitsuhashi, Hiroshi</creatorcontrib><creatorcontrib>Yanagi, Mai</creatorcontrib><creatorcontrib>Oshikawa, Jin</creatorcontrib><creatorcontrib>Uneda, Kazushi</creatorcontrib><creatorcontrib>Aoki, Kazutaka</creatorcontrib><creatorcontrib>Fujikawa, Tetsuya</creatorcontrib><creatorcontrib>Toya, Yoshiyuki</creatorcontrib><creatorcontrib>Uchino, Kazuaki</creatorcontrib><creatorcontrib>Umemura, Satoshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The journal of clinical hypertension (Greenwich, Conn.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kanaoka, Tomohiko</au><au>Tamura, Kouichi</au><au>Ohsawa, Masato</au><au>Wakui, Hiromichi</au><au>Maeda, Akinobu</au><au>Dejima, Toru</au><au>Azushima, Kengo</au><au>Haku, Sona</au><au>Mitsuhashi, Hiroshi</au><au>Yanagi, Mai</au><au>Oshikawa, Jin</au><au>Uneda, Kazushi</au><au>Aoki, Kazutaka</au><au>Fujikawa, Tetsuya</au><au>Toya, Yoshiyuki</au><au>Uchino, Kazuaki</au><au>Umemura, Satoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Aliskiren‐Based Therapy on Ambulatory Blood Pressure Profile, Central Hemodynamics, and Arterial Stiffness in Nondiabetic Mild to Moderate Hypertensive Patients</atitle><jtitle>The journal of clinical hypertension (Greenwich, Conn.)</jtitle><addtitle>J Clin Hypertens (Greenwich)</addtitle><date>2012-08</date><risdate>2012</risdate><volume>14</volume><issue>8</issue><spage>522</spage><epage>529</epage><pages>522-529</pages><issn>1524-6175</issn><eissn>1751-7176</eissn><abstract>J Clin Hypertens (Greenwich). 2012;00:000–000. ©2012 Wiley Periodicals, Inc.
Aliskiren is a direct renin inhibitor that exerts its effect at the rate‐limiting step of the renin‐angiotensin system. This study was performed to examine the beneficial effects of aliskiren‐based antihypertensive therapy on the ambulatory blood pressure (BP) profile, central hemodybamics, and arterial stiffness in untreated Japanese patients with mild to moderate hypertension. Twenty‐one Japanese nondiabetic patients with untreated mild to moderate essential hypertension were initially given aliskiren once daily at 150 mg, and the dose was titrated up to 300 mg as needed. After 12 weeks of aliskiren‐based therapy, the clinic, ambulatory, and central BP values as well as brachial‐ankle pulse wave velocity (baPWV) were all significantly decreased compared with baseline (clinic systolic BP, 151±11 mm Hg vs 132±11 mm Hg; clinic diastolic BP, 91±13 mm Hg vs 82±9 mm Hg; 24‐hour systolic BP, 144±12 mm Hg vs 133±11 mm Hg; 24‐hour diastolic BP, 88±8 mm Hg vs 81±9 mm Hg; central BP, 162±16 mm Hg vs 148±14 mm Hg; baPWV, 1625±245 cm/s vs 1495±199 cm/s; P<.05). These results show that aliskiren, as a first‐line regimen, improves the ambulatory BP profile and may have protective vascular effects in Japanese nondiabetic patients with untreated mild to moderate essential hypertension.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>22863160</pmid><doi>10.1111/j.1751-7176.2012.00640.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The journal of clinical hypertension (Greenwich, Conn.), 2012-08, Vol.14 (8), p.522-529 |
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| subjects | Aged Amides - pharmacology Amides - therapeutic use Antihypertensive Agents - pharmacology Antihypertensive Agents - therapeutic use Blood Pressure - drug effects Blood Pressure - physiology Blood Pressure Monitoring, Ambulatory Dose-Response Relationship, Drug Female Fumarates - pharmacology Fumarates - therapeutic use Hemodynamics - drug effects Hemodynamics - physiology Humans Hypertension - drug therapy Hypertension - ethnology Hypertension - physiopathology Japan Male Middle Aged Original Paper Original Papers Prospective Studies Renin-Angiotensin System - drug effects Renin-Angiotensin System - physiology Retrospective Studies Severity of Illness Index Treatment Outcome Vascular Stiffness - drug effects Vascular Stiffness - physiology |
| title | Effects of Aliskiren‐Based Therapy on Ambulatory Blood Pressure Profile, Central Hemodynamics, and Arterial Stiffness in Nondiabetic Mild to Moderate Hypertensive Patients |
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