Detection and genotyping of bovine viral diarrhea virus found contaminating commercial veterinary vaccines, cell lines, and fetal bovine serum lots originating in Mexico
In this communication, we report the presence of RNA of bovine viral diarrhea virus (BVDV) as a contaminant of different biological products used in Mexico for veterinary vaccine production. For this purpose, six batches of monovalent vaccines, eight cell line batches used for vaccine production, an...
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| Veröffentlicht in: | Archives of virology 2021-07, Vol.166 (7), p.1999-2003 |
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| creator | Gómez-Romero, Ninnet Velazquez-Salinas, Lauro Ridpath, Julia F. Verdugo-Rodríguez, Antonio Basurto-Alcántara, Francisco Javier |
| description | In this communication, we report the presence of RNA of bovine viral diarrhea virus (BVDV) as a contaminant of different biological products used in Mexico for veterinary vaccine production. For this purpose, six batches of monovalent vaccines, eight cell line batches used for vaccine production, and 10 fetal bovine serum lots (FBS) commercially available in Mexico from different suppliers were tested by reverse transcription polymerase chain reaction (RT-PCR). Viral RNA was detected in 62.5% of the samples analyzed. Phylogenetic analysis revealed the presence of the subgenotypes BVDV-1a, 1b, and BVDV-2a in the tested samples. Collectively, these findings indicate that contamination by BVDV RNA occurs in commercial vaccines and reagents used in research and production of biological products. The ramifications of this contamination are discussed. |
| doi_str_mv | 10.1007/s00705-021-05089-9 |
| format | Article |
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For this purpose, six batches of monovalent vaccines, eight cell line batches used for vaccine production, and 10 fetal bovine serum lots (FBS) commercially available in Mexico from different suppliers were tested by reverse transcription polymerase chain reaction (RT-PCR). Viral RNA was detected in 62.5% of the samples analyzed. Phylogenetic analysis revealed the presence of the subgenotypes BVDV-1a, 1b, and BVDV-2a in the tested samples. Collectively, these findings indicate that contamination by BVDV RNA occurs in commercial vaccines and reagents used in research and production of biological products. The ramifications of this contamination are discussed.</description><identifier>ISSN: 0304-8608</identifier><identifier>EISSN: 1432-8798</identifier><identifier>DOI: 10.1007/s00705-021-05089-9</identifier><identifier>PMID: 33970345</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Animals ; Biomedical and Life Sciences ; Biomedicine ; Bovine Virus Diarrhea-Mucosal Disease - immunology ; Brief Report ; Cattle ; Cell Line ; Cell lines ; Contaminants ; Contamination ; Diarrhea ; Diarrhea Virus 1, Bovine Viral - genetics ; Diarrhea Virus 1, Bovine Viral - immunology ; Diarrhea Virus 2, Bovine Viral - genetics ; Diarrhea Virus 2, Bovine Viral - immunology ; Fetal calf serum ; Genotype ; Genotyping ; Hemorrhagic Syndrome, Bovine - microbiology ; Infectious Diseases ; Medical Microbiology ; Mexico ; Phylogeny ; Polymerase chain reaction ; Reverse transcription ; Ribonucleic acid ; RNA ; RNA, Viral - genetics ; Vaccines ; Viral Vaccines - genetics ; Viral Vaccines - immunology ; Virology</subject><ispartof>Archives of virology, 2021-07, Vol.166 (7), p.1999-2003</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-d7487fd2e3ab81594782da0576fc2be405bce7d03b7228777d0546bcf48c6eb93</citedby><cites>FETCH-LOGICAL-c474t-d7487fd2e3ab81594782da0576fc2be405bce7d03b7228777d0546bcf48c6eb93</cites><orcidid>0000-0003-2085-7987 ; 0000-0003-3325-5694 ; 0000-0001-7182-8161</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00705-021-05089-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00705-021-05089-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33970345$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gómez-Romero, Ninnet</creatorcontrib><creatorcontrib>Velazquez-Salinas, Lauro</creatorcontrib><creatorcontrib>Ridpath, Julia F.</creatorcontrib><creatorcontrib>Verdugo-Rodríguez, Antonio</creatorcontrib><creatorcontrib>Basurto-Alcántara, Francisco Javier</creatorcontrib><title>Detection and genotyping of bovine viral diarrhea virus found contaminating commercial veterinary vaccines, cell lines, and fetal bovine serum lots originating in Mexico</title><title>Archives of virology</title><addtitle>Arch Virol</addtitle><addtitle>Arch Virol</addtitle><description>In this communication, we report the presence of RNA of bovine viral diarrhea virus (BVDV) as a contaminant of different biological products used in Mexico for veterinary vaccine production. For this purpose, six batches of monovalent vaccines, eight cell line batches used for vaccine production, and 10 fetal bovine serum lots (FBS) commercially available in Mexico from different suppliers were tested by reverse transcription polymerase chain reaction (RT-PCR). Viral RNA was detected in 62.5% of the samples analyzed. Phylogenetic analysis revealed the presence of the subgenotypes BVDV-1a, 1b, and BVDV-2a in the tested samples. Collectively, these findings indicate that contamination by BVDV RNA occurs in commercial vaccines and reagents used in research and production of biological products. The ramifications of this contamination are discussed.</description><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bovine Virus Diarrhea-Mucosal Disease - immunology</subject><subject>Brief Report</subject><subject>Cattle</subject><subject>Cell Line</subject><subject>Cell lines</subject><subject>Contaminants</subject><subject>Contamination</subject><subject>Diarrhea</subject><subject>Diarrhea Virus 1, Bovine Viral - genetics</subject><subject>Diarrhea Virus 1, Bovine Viral - immunology</subject><subject>Diarrhea Virus 2, Bovine Viral - genetics</subject><subject>Diarrhea Virus 2, Bovine Viral - immunology</subject><subject>Fetal calf serum</subject><subject>Genotype</subject><subject>Genotyping</subject><subject>Hemorrhagic Syndrome, Bovine - microbiology</subject><subject>Infectious Diseases</subject><subject>Medical Microbiology</subject><subject>Mexico</subject><subject>Phylogeny</subject><subject>Polymerase chain reaction</subject><subject>Reverse transcription</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA, Viral - genetics</subject><subject>Vaccines</subject><subject>Viral Vaccines - genetics</subject><subject>Viral Vaccines - immunology</subject><subject>Virology</subject><issn>0304-8608</issn><issn>1432-8798</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kstu1TAQhi0EoqeFF2CBLLFhQcB27GNng4QKBaQiNrC2HGeSukrsg-1E9JF4SxxyWi4LNr6Mv_nHv2YQekLJS0qIfJXKQkRFGK2IIKqpmntoR3nNKiUbdR_tSE14pfZEnaDTlK4JKYFaPEQndd1IUnOxQz_eQgabXfDY-A4P4EO-OTg_4NDjNizOA15cNCPunInxCsx6nRPuw1x4G3w2k_Mmryk2TBNE6wq9FNlY4vEGL8baIpNeYAvjiMftvFbrIRf0WCVBnCc8hpxwiG641XQef4LvzoZH6EFvxgSPj_sZ-nrx7sv5h-ry8_uP528uK8slz1UnuZJ9x6A2raKi4VKxzhAh971lLXAiWguyI3UrGVNSlqPg-9b2XNk9tE19hl5vuoe5naCz4HOxrw_RTcWNDsbpv1-8u9JDWLSiRHJGi8Dzo0AM32ZIWU8urdaNhzAnzQTjSlGqVvTZP-h1mKMv9grFS78EU_tCsY2yMaQUob_7DCV6nQS9TYIuk6B_TYJebTz908Zdym3rC1BvQCpPfoD4u_Z_ZH8CpeTDdQ</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Gómez-Romero, Ninnet</creator><creator>Velazquez-Salinas, Lauro</creator><creator>Ridpath, Julia F.</creator><creator>Verdugo-Rodríguez, Antonio</creator><creator>Basurto-Alcántara, Francisco Javier</creator><general>Springer Vienna</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2085-7987</orcidid><orcidid>https://orcid.org/0000-0003-3325-5694</orcidid><orcidid>https://orcid.org/0000-0001-7182-8161</orcidid></search><sort><creationdate>20210701</creationdate><title>Detection and genotyping of bovine viral diarrhea virus found contaminating commercial veterinary vaccines, cell lines, and fetal bovine serum lots originating in Mexico</title><author>Gómez-Romero, Ninnet ; Velazquez-Salinas, Lauro ; Ridpath, Julia F. ; Verdugo-Rodríguez, Antonio ; Basurto-Alcántara, Francisco Javier</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-d7487fd2e3ab81594782da0576fc2be405bce7d03b7228777d0546bcf48c6eb93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Bovine Virus Diarrhea-Mucosal Disease - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Archives of virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gómez-Romero, Ninnet</au><au>Velazquez-Salinas, Lauro</au><au>Ridpath, Julia F.</au><au>Verdugo-Rodríguez, Antonio</au><au>Basurto-Alcántara, Francisco Javier</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detection and genotyping of bovine viral diarrhea virus found contaminating commercial veterinary vaccines, cell lines, and fetal bovine serum lots originating in Mexico</atitle><jtitle>Archives of virology</jtitle><stitle>Arch Virol</stitle><addtitle>Arch Virol</addtitle><date>2021-07-01</date><risdate>2021</risdate><volume>166</volume><issue>7</issue><spage>1999</spage><epage>2003</epage><pages>1999-2003</pages><issn>0304-8608</issn><eissn>1432-8798</eissn><abstract>In this communication, we report the presence of RNA of bovine viral diarrhea virus (BVDV) as a contaminant of different biological products used in Mexico for veterinary vaccine production. For this purpose, six batches of monovalent vaccines, eight cell line batches used for vaccine production, and 10 fetal bovine serum lots (FBS) commercially available in Mexico from different suppliers were tested by reverse transcription polymerase chain reaction (RT-PCR). Viral RNA was detected in 62.5% of the samples analyzed. Phylogenetic analysis revealed the presence of the subgenotypes BVDV-1a, 1b, and BVDV-2a in the tested samples. Collectively, these findings indicate that contamination by BVDV RNA occurs in commercial vaccines and reagents used in research and production of biological products. 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| subjects | Animals Biomedical and Life Sciences Biomedicine Bovine Virus Diarrhea-Mucosal Disease - immunology Brief Report Cattle Cell Line Cell lines Contaminants Contamination Diarrhea Diarrhea Virus 1, Bovine Viral - genetics Diarrhea Virus 1, Bovine Viral - immunology Diarrhea Virus 2, Bovine Viral - genetics Diarrhea Virus 2, Bovine Viral - immunology Fetal calf serum Genotype Genotyping Hemorrhagic Syndrome, Bovine - microbiology Infectious Diseases Medical Microbiology Mexico Phylogeny Polymerase chain reaction Reverse transcription Ribonucleic acid RNA RNA, Viral - genetics Vaccines Viral Vaccines - genetics Viral Vaccines - immunology Virology |
| title | Detection and genotyping of bovine viral diarrhea virus found contaminating commercial veterinary vaccines, cell lines, and fetal bovine serum lots originating in Mexico |
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