YAP1 and its fusion proteins in cancer initiation, progression and therapeutic resistance

YAP1 is a transcriptional co-activator whose activity is controlled by the Hippo signaling pathway. In addition to important functions in normal tissue homeostasis and regeneration, YAP1 has also prominent functions in cancer initiation, aggressiveness, metastasis, and therapy resistance. In this re...

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Veröffentlicht in:	Developmental biology 2021-07, Vol.475, p.205-221
Hauptverfasser:	Szulzewsky, Frank, Holland, Eric C., Vasioukhin, Valeri
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Adaptor Proteins, Signal Transducing - physiology Animals Cancer Drug Resistance, Neoplasm - genetics Gene Expression Regulation, Neoplastic - genetics Gene fusions Hippo signaling pathway Humans Neoplasms - genetics Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - metabolism Oncogenes - genetics Phosphoproteins - genetics Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Signal Transduction - genetics Transcription Factors - genetics Transcription Factors - metabolism Transcription Factors - physiology YAP-Signaling Proteins YAP1 YAP1 fusion
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