Impact of high-dose folic acid supplementation in pregnancy on biomarkers of folate status and 1-carbon metabolism: An ancillary study of the Folic Acid Clinical Trial (FACT)

Periconceptional folic acid (FA) supplementation is recommended to prevent the occurrence of neural tube defects. Currently, most over-the-counter FA supplements in Canada and the United States contain 1 mg FA and some women are prescribed 5 mg FA/d. High-dose FA is hypothesized to impair 1-carbon m...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The American journal of clinical nutrition 2021-05, Vol.113 (5), p.1361-1371
Hauptverfasser:	Murphy, Malia SQ, Muldoon, Katherine A, Sheyholislami, Hauna, Behan, Nathalie, Lamers, Yvonne, Rybak, Natalie, White, Ruth Rennicks, Harvey, Alysha LJ, Gaudet, Laura M, Smith, Graeme N, Walker, Mark C, Wen, Shi Wu, MacFarlane, Amanda J
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - genetics 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - metabolism Acids Biomarkers Biomarkers - blood Carbon Clinical trials Dietary Supplements Dosage Dose-Response Relationship, Drug Double-Blind Method Female folate folate status Folic acid Folic Acid - administration & dosage Folic Acid - pharmacology Gene Expression Regulation - drug effects Homocysteine Humans Metabolism Methylenetetrahydrofolate Dehydrogenase (NADP) - genetics Methylenetetrahydrofolate Dehydrogenase (NADP) - metabolism Methylenetetrahydrofolate Reductase (NADPH2) - genetics Methylenetetrahydrofolate Reductase (NADPH2) - metabolism Minor Histocompatibility Antigens - genetics Minor Histocompatibility Antigens - metabolism Neural tube defects Original Research Communications Oxidation Placebos Polymorphism, Single Nucleotide Pre-eclampsia Preeclampsia Pregnancy supplementation Supplements Tetrahydrofolic acid Triazine Vitamin B Vitamin B Complex - administration & dosage Vitamin B Complex - pharmacology Vitamins
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!