Divergent low-density lipoprotein receptor (LDLR) linked to low VSV G-dependent viral infectivity and unique serum lipid profile in zebra finches

The low-density lipoprotein receptor (LDLR) is key to cellular cholesterol uptake and is also the main receptor for the vesicular stomatitis virus glycoprotein (VSV G). Here we show that in songbirds LDLR is highly divergent and lacks domains critical for ligand binding and cellular trafficking, inc...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2021-05, Vol.118 (18), p.1-3
Hauptverfasser:	Velho, Tarciso A. F., Lovell, Peter V., Friedrich, Samantha R., Olson, Christopher R., Miles, Joshua, Mueller, Paul A., Tavori, Hagai, Fazio, Sergio, Lois, Carlos, Mello, Claudio V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Biological Transport - genetics BRIEF REPORTS Cellular structure Cholesterol Cholesterol - genetics Cholesterol - metabolism Density Divergence Domains Finches - blood Finches - genetics Gene Expression Regulation - genetics Genetics Glycoproteins High density lipoprotein Humans Infectivity Ligands Lipids Lipids - blood Lipoproteins Low density lipoprotein receptors Membrane Glycoproteins - genetics Receptor density Receptors Receptors, LDL - blood Receptors, LDL - genetics Songbirds Stomatitis Structure-function relationships Vertebrates Viral Envelope Proteins - genetics Viruses
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