Coronary computed tomographic angiography imaging as a prognostic indicator for coronary artery disease: Data from a lebanese tertiary center
Background: Coronary artery disease (CAD) is a major cause of death and disability worldwide. Coronary computed tomographic angiography (CCTA) is a noninvasive imaging technique with a high negative predictive value (NPV). Most studies were done in developed countries, where the prevalence of CAD do...
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| Veröffentlicht in: | Heart views 2020-10, Vol.21 (4), p.239-244 |
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| creator | Koubaissi, Salwa Kamar, Zeinab El Ankouni, Mahdi Degheili, Jad Haddad, Antoine |
| description | Background: Coronary artery disease (CAD) is a major cause of death and disability worldwide. Coronary computed tomographic angiography (CCTA) is a noninvasive imaging technique with a high negative predictive value (NPV). Most studies were done in developed countries, where the prevalence of CAD does not reflect the actual disease burden in developing countries, such as Lebanon.
Methods: We retrospectively evaluated the prognostic value of CCTA in predicting acute myocardial events (AMEs) in 200 Lebanese patients. We determined if specific medical and radiological characteristics are linked with AME and looked for any association between the patient's medical risk factors and the type/location of detected atheromatous plaques. Patients' records were reviewed, and the follow-up period of 5-8 years ensued. Chi-square/Fisher test and Student's t-test were used, in addition to multinomial logistic regression to adjust for the confounding variables. P |
| doi_str_mv | 10.4103/HEARTVIEWS.HEARTVIEWS_87_20 |
| format | Article |
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Methods: We retrospectively evaluated the prognostic value of CCTA in predicting acute myocardial events (AMEs) in 200 Lebanese patients. We determined if specific medical and radiological characteristics are linked with AME and looked for any association between the patient's medical risk factors and the type/location of detected atheromatous plaques. Patients' records were reviewed, and the follow-up period of 5-8 years ensued. Chi-square/Fisher test and Student's t-test were used, in addition to multinomial logistic regression to adjust for the confounding variables. P<0.05 was considered statistically significant.
Results: Our study showed that CCTA had a NPV that reaches 97.9% in asymptomatic patients, a positive predictive value (PPV) of 76.4% for symptomatic patients, a sensitivity of 88.9%, and a specificity of 52.5%. AMEs were significantly increased in patients with a mixed plaque type and/or a moderate-to-severe lumen reduction on CCTA.
Conclusions: CCTA is a sensitive modality for plaque detection and is found to have a remarkably high NPV for asymptomatic patients. A CCTA, along with a low pretest clinical probability of CAD, can be sufficient to rule out an AME for up to 8 years.</description><identifier>ISSN: 1995-705X</identifier><identifier>EISSN: 0976-5123</identifier><identifier>DOI: 10.4103/HEARTVIEWS.HEARTVIEWS_87_20</identifier><identifier>PMID: 33986921</identifier><language>eng</language><publisher>India: Wolters Kluwer India Pvt. Ltd</publisher><subject>Angiography ; Asymptomatic ; Cardiovascular disease ; Coronary heart disease ; Coronary vessels ; Developing countries ; Medical imaging ; Original</subject><ispartof>Heart views, 2020-10, Vol.21 (4), p.239-244</ispartof><rights>Copyright: © 2021 Heart Views.</rights><rights>COPYRIGHT 2020 Medknow Publications and Media Pvt. Ltd.</rights><rights>2020. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright: © 2021 Heart Views 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8104316/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8104316/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27435,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33986921$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koubaissi, Salwa</creatorcontrib><creatorcontrib>Kamar, Zeinab</creatorcontrib><creatorcontrib>El Ankouni, Mahdi</creatorcontrib><creatorcontrib>Degheili, Jad</creatorcontrib><creatorcontrib>Haddad, Antoine</creatorcontrib><title>Coronary computed tomographic angiography imaging as a prognostic indicator for coronary artery disease: Data from a lebanese tertiary center</title><title>Heart views</title><addtitle>Heart Views</addtitle><description>Background: Coronary artery disease (CAD) is a major cause of death and disability worldwide. Coronary computed tomographic angiography (CCTA) is a noninvasive imaging technique with a high negative predictive value (NPV). Most studies were done in developed countries, where the prevalence of CAD does not reflect the actual disease burden in developing countries, such as Lebanon.
Methods: We retrospectively evaluated the prognostic value of CCTA in predicting acute myocardial events (AMEs) in 200 Lebanese patients. We determined if specific medical and radiological characteristics are linked with AME and looked for any association between the patient's medical risk factors and the type/location of detected atheromatous plaques. Patients' records were reviewed, and the follow-up period of 5-8 years ensued. Chi-square/Fisher test and Student's t-test were used, in addition to multinomial logistic regression to adjust for the confounding variables. P<0.05 was considered statistically significant.
Results: Our study showed that CCTA had a NPV that reaches 97.9% in asymptomatic patients, a positive predictive value (PPV) of 76.4% for symptomatic patients, a sensitivity of 88.9%, and a specificity of 52.5%. AMEs were significantly increased in patients with a mixed plaque type and/or a moderate-to-severe lumen reduction on CCTA.
Conclusions: CCTA is a sensitive modality for plaque detection and is found to have a remarkably high NPV for asymptomatic patients. A CCTA, along with a low pretest clinical probability of CAD, can be sufficient to rule out an AME for up to 8 years.</description><subject>Angiography</subject><subject>Asymptomatic</subject><subject>Cardiovascular disease</subject><subject>Coronary heart disease</subject><subject>Coronary vessels</subject><subject>Developing countries</subject><subject>Medical imaging</subject><subject>Original</subject><issn>1995-705X</issn><issn>0976-5123</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkl2LEzEUhgdR3Lr6F2RgQbxpzcd8RWGh1OourAha1LuQyZyZZncmqcmMpT_C_-yp3e62ixcShiST530PJ3mj6IySSUIJf3Mxn35ZfLucf_86uV_KIpeMPIpGROTZOKWMP45GVIh0nJP0x0n0LIRrQtIsIeJpdMK5KDLB6Cj6PXPeWeU3sXbdauihinvXucar1dLoWNnG7Dab2HSqMbaJVYhVvPKusS70yBhbGa165-MaP733U74HnCoTQAV4G79XvYpr7zpUt1AqCwFiRHrztzpYXD-PntSqDfDidj6NFh_mi9nF-Orzx8vZ9GqsE5FvxpWAhAHJMi14UXFKSl3ykvCyJIqVXDNIRJmnpCBa53mlBFGIbHeUqwL4aXS-s10NZQfVtrZXrVx5bNFvpFNGHp9Ys5SN-yULShJOMzR4fWvg3c8BQi87EzS0LXblhiBZygqaF5QJRM8eoNdu8Ba7Q4qzFJ8hI_dUo1qQxtYO6-qtqZxmiaB5XhQJUpN_UDgq6Ix2FmqD_48Erw4ES1BtvwyuHXrjbDgG3-1A7V0IHuq7y6BEblMnD6L2MHWofnl4n3fafcwQ-LQD1q7FZw437bAGL5G9sW79PzUk40Lus8r_ABvz84w</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Koubaissi, Salwa</creator><creator>Kamar, Zeinab</creator><creator>El Ankouni, Mahdi</creator><creator>Degheili, Jad</creator><creator>Haddad, Antoine</creator><general>Wolters Kluwer India Pvt. 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Coronary computed tomographic angiography (CCTA) is a noninvasive imaging technique with a high negative predictive value (NPV). Most studies were done in developed countries, where the prevalence of CAD does not reflect the actual disease burden in developing countries, such as Lebanon.
Methods: We retrospectively evaluated the prognostic value of CCTA in predicting acute myocardial events (AMEs) in 200 Lebanese patients. We determined if specific medical and radiological characteristics are linked with AME and looked for any association between the patient's medical risk factors and the type/location of detected atheromatous plaques. Patients' records were reviewed, and the follow-up period of 5-8 years ensued. Chi-square/Fisher test and Student's t-test were used, in addition to multinomial logistic regression to adjust for the confounding variables. P<0.05 was considered statistically significant.
Results: Our study showed that CCTA had a NPV that reaches 97.9% in asymptomatic patients, a positive predictive value (PPV) of 76.4% for symptomatic patients, a sensitivity of 88.9%, and a specificity of 52.5%. AMEs were significantly increased in patients with a mixed plaque type and/or a moderate-to-severe lumen reduction on CCTA.
Conclusions: CCTA is a sensitive modality for plaque detection and is found to have a remarkably high NPV for asymptomatic patients. A CCTA, along with a low pretest clinical probability of CAD, can be sufficient to rule out an AME for up to 8 years.</abstract><cop>India</cop><pub>Wolters Kluwer India Pvt. Ltd</pub><pmid>33986921</pmid><doi>10.4103/HEARTVIEWS.HEARTVIEWS_87_20</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Heart views, 2020-10, Vol.21 (4), p.239-244 |
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| subjects | Angiography Asymptomatic Cardiovascular disease Coronary heart disease Coronary vessels Developing countries Medical imaging Original |
| title | Coronary computed tomographic angiography imaging as a prognostic indicator for coronary artery disease: Data from a lebanese tertiary center |
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