ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity

Activation of the RIG-I-like receptors, retinoic-acid inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5), establishes an antiviral state by upregulating interferon (IFN)-stimulated genes (ISGs). Among these is ISG15, the mechanistic roles of which in innate immunity st...

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Veröffentlicht in:	Nature microbiology 2021-04, Vol.6 (4), p.467-478
Hauptverfasser:	Liu, GuanQun, Lee, Jung-Hyun, Parker, Zachary M., Acharya, Dhiraj, Chiang, Jessica J., van Gent, Michiel, Riedl, William, Davis-Gardner, Meredith E., Wies, Effi, Chiang, Cindy, Gack, Michaela U.
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/109 13/21 13/31 38 38/89 38/90 631/250 631/250/262 631/250/262/2106 631/250/262/2106/2518 82/29 82/58 96 96/95 Aedes Animals Antiviral agents Antiviral state Biomedical and Life Sciences Caspase Chlorocebus aethiops Coronaviridae Coronavirus Papain-Like Proteases - metabolism Coronaviruses COVID-19 Cricetinae Cytokines - metabolism HEK293 Cells Humans Immunity, Innate Infectious Diseases Innate immunity Interferon Interferon-Induced Helicase, IFIH1 - antagonists & inhibitors Interferon-Induced Helicase, IFIH1 - metabolism Leukocytes, Mononuclear Life Sciences Medical Microbiology Melanoma Mice Microbiology Oligomerization Pandemics Papain Parasitology Proteinase SARS-CoV-2 - enzymology SARS-CoV-2 - immunology Severe acute respiratory syndrome coronavirus 2 Ubiquitins - metabolism Vero Cells Virology
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