A bioactive molecule made by unusual salvage of radical SAM enzyme byproduct 5-deoxyadenosine blurs the boundary of primary and secondary metabolism

5-Deoxyadenosine (5dAdo) is the byproduct of many radical S-adenosyl-l-methionine enzyme reactions in all domains of life. 5dAdo is also an inhibitor of the radical S-adenosyl-l-methionine enzymes themselves, making it necessary for cells to construct pathways to recycle or dispose of this toxic met...

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Veröffentlicht in:	The Journal of biological chemistry 2021-01, Vol.296, p.100621, Article 100621
Hauptverfasser:	Rapp, Johanna, Rath, Pascal, Kilian, Joachim, Brilisauer, Klaus, Grond, Stephanie, Forchhammer, Karl
Format:	Artikel
Sprache:	eng
Schlagworte:	5-deoxyadenosine salvage 5-deoxyribose 7-deoxysedoheptulose biosynthesis carbohydrate biosynthesis cyanobacteria enzyme promiscuity GC–MS radical SAM enzymes S-adenosylmethionine secondary metabolism
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