SWI/SNF Complex Mutations Promote Thyroid Tumor Progression and Insensitivity to Redifferentiation Therapies

Mutations of subunits of the SWI/SNF chromatin remodeling complexes occur commonly in cancers of different lineages, including advanced thyroid cancers. Here we show that thyroid-specific loss of , or in mouse BRAF -mutant tumors promotes disease progression and decreased survival, associated with l...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Cancer discovery 2021-05, Vol.11 (5), p.1158-1175
Hauptverfasser:	Saqcena, Mahesh, Leandro-Garcia, Luis Javier, Maag, Jesper L V, Tchekmedyian, Vatche, Krishnamoorthy, Gnana P, Tamarapu, Prasanna P, Tiedje, Vera, Reuter, Vincent, Knauf, Jeffrey A, de Stanchina, Elisa, Xu, Bin, Liao, Xiao-Hui, Refetoff, Samuel, Ghossein, Ronald, Chi, Ping, Ho, Alan L, Koche, Richard P, Fagin, James A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Cellular Reprogramming Techniques Chromosomal Proteins, Non-Histone - genetics Disease Models, Animal Mice Mice, Inbred Strains Mutation Thyroid Neoplasms - genetics Thyroid Neoplasms - metabolism Thyroid Neoplasms - pathology Transcription Factors - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!