Genetic Testing for Parkinson Disease: Are We Ready?
With the advent of precision medicine and demand for genomic testing information, we may question whether it is time to offer genetic testing to our patients with Parkinson disease (PD). This review updates the current genetic landscape of PD, describes what genetic testing may offer, provides strat...
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| Veröffentlicht in: | Neurology. Clinical practice 2021-02, Vol.11 (1), p.69-77 |
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| container_title | Neurology. Clinical practice |
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| creator | Cook, Lola Schulze, Jeanine Kopil, Catherine Hastings, Tara Naito, Anna Wojcieszek, Joanne Payne, Katelyn Alcalay, Roy N. Klein, Christine Saunders-Pullman, Rachel Simuni, Tatyana Foroud, Tatiana |
| description | With the advent of precision medicine and demand for genomic testing information, we may question whether it is time to offer genetic testing to our patients with Parkinson disease (PD). This review updates the current genetic landscape of PD, describes what genetic testing may offer, provides strategies for evaluating whom to test, and provides resources for the busy clinician.
Patients with PD and their relatives, in various settings, have expressed an interest in learning their PD genetic status; however, physicians may be hesitant to widely offer testing due to the perceived low clinical utility of PD genetic test results. The rise of clinical trials available for patients with gene-specific PD and emerging information on genotype-phenotype correlations are starting to shift this discussion about testing.
By learning more about the various genetic testing options for PD and utility of results for patients and their care, clinicians may become more comfortable with widespread PD genetic testing in the research and clinical setting. |
| doi_str_mv | 10.1212/CPJ.0000000000000831 |
| format | Article |
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Patients with PD and their relatives, in various settings, have expressed an interest in learning their PD genetic status; however, physicians may be hesitant to widely offer testing due to the perceived low clinical utility of PD genetic test results. The rise of clinical trials available for patients with gene-specific PD and emerging information on genotype-phenotype correlations are starting to shift this discussion about testing.
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Patients with PD and their relatives, in various settings, have expressed an interest in learning their PD genetic status; however, physicians may be hesitant to widely offer testing due to the perceived low clinical utility of PD genetic test results. The rise of clinical trials available for patients with gene-specific PD and emerging information on genotype-phenotype correlations are starting to shift this discussion about testing.
By learning more about the various genetic testing options for PD and utility of results for patients and their care, clinicians may become more comfortable with widespread PD genetic testing in the research and clinical setting.</description><subject>Review</subject><issn>2163-0402</issn><issn>2163-0933</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpdkFtLAzEQhYMoKtV_ILKPvmzNbbNZHxSpWhVBkYKPIZvM2uh2o8lW8d-b0noNHDKQmTM5H0J7BA8JJfRwdHc9xL-PZGQNbVMiWI4rxta_ao7pFtqN8WnRJDBhtNpEW4xVQvKy2EZ8DB30zmQTiL3rHrPGh-xOh2fXRd9lZy6CjnCUnQbIHiC7B20_TnbQRqPbCLure4AmF-eT0WV-czu-Gp3e5IYVabkpubVGk1I3YGusRUVYKYiwurbG2oKVtqgZSGEkroW10hJe4SaJiIpJNkDHS9uXeT0Da6Drg27VS3AzHT6U1079fencVD36NyVJCpriD9DByiD413kKqGYuGmhb3YGfR0ULymXJeCI2QHzZaoKPMUDzvYZgtUCuEnL1H3ka2__9xe-hL8A_vu--7SHE53b-DkFNQbf9VGFSSJGUU0wJpsk0TyKMfQKguIrC</recordid><startdate>20210201</startdate><enddate>20210201</enddate><creator>Cook, Lola</creator><creator>Schulze, Jeanine</creator><creator>Kopil, Catherine</creator><creator>Hastings, Tara</creator><creator>Naito, Anna</creator><creator>Wojcieszek, Joanne</creator><creator>Payne, Katelyn</creator><creator>Alcalay, Roy N.</creator><creator>Klein, Christine</creator><creator>Saunders-Pullman, Rachel</creator><creator>Simuni, Tatyana</creator><creator>Foroud, Tatiana</creator><general>Lippincott Williams & Wilkins</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5717-4875</orcidid></search><sort><creationdate>20210201</creationdate><title>Genetic Testing for Parkinson Disease: Are We Ready?</title><author>Cook, Lola ; Schulze, Jeanine ; Kopil, Catherine ; Hastings, Tara ; Naito, Anna ; Wojcieszek, Joanne ; Payne, Katelyn ; Alcalay, Roy N. ; Klein, Christine ; Saunders-Pullman, Rachel ; Simuni, Tatyana ; Foroud, Tatiana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3563-c74ddca17afedb0a69137616dabdcdd537d5b3e86c80b6dd8d1490f490169383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cook, Lola</creatorcontrib><creatorcontrib>Schulze, Jeanine</creatorcontrib><creatorcontrib>Kopil, Catherine</creatorcontrib><creatorcontrib>Hastings, Tara</creatorcontrib><creatorcontrib>Naito, Anna</creatorcontrib><creatorcontrib>Wojcieszek, Joanne</creatorcontrib><creatorcontrib>Payne, Katelyn</creatorcontrib><creatorcontrib>Alcalay, Roy N.</creatorcontrib><creatorcontrib>Klein, Christine</creatorcontrib><creatorcontrib>Saunders-Pullman, Rachel</creatorcontrib><creatorcontrib>Simuni, Tatyana</creatorcontrib><creatorcontrib>Foroud, Tatiana</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neurology. Clinical practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cook, Lola</au><au>Schulze, Jeanine</au><au>Kopil, Catherine</au><au>Hastings, Tara</au><au>Naito, Anna</au><au>Wojcieszek, Joanne</au><au>Payne, Katelyn</au><au>Alcalay, Roy N.</au><au>Klein, Christine</au><au>Saunders-Pullman, Rachel</au><au>Simuni, Tatyana</au><au>Foroud, Tatiana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic Testing for Parkinson Disease: Are We Ready?</atitle><jtitle>Neurology. Clinical practice</jtitle><addtitle>Neurol Clin Pract</addtitle><date>2021-02-01</date><risdate>2021</risdate><volume>11</volume><issue>1</issue><spage>69</spage><epage>77</epage><pages>69-77</pages><issn>2163-0402</issn><eissn>2163-0933</eissn><abstract>With the advent of precision medicine and demand for genomic testing information, we may question whether it is time to offer genetic testing to our patients with Parkinson disease (PD). This review updates the current genetic landscape of PD, describes what genetic testing may offer, provides strategies for evaluating whom to test, and provides resources for the busy clinician.
Patients with PD and their relatives, in various settings, have expressed an interest in learning their PD genetic status; however, physicians may be hesitant to widely offer testing due to the perceived low clinical utility of PD genetic test results. The rise of clinical trials available for patients with gene-specific PD and emerging information on genotype-phenotype correlations are starting to shift this discussion about testing.
By learning more about the various genetic testing options for PD and utility of results for patients and their care, clinicians may become more comfortable with widespread PD genetic testing in the research and clinical setting.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins</pub><pmid>33968475</pmid><doi>10.1212/CPJ.0000000000000831</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-5717-4875</orcidid></addata></record> |
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| subjects | Review |
| title | Genetic Testing for Parkinson Disease: Are We Ready? |
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