Artemisinin susceptibility in the malaria parasite Plasmodium falciparum: propellers, adaptor proteins and the need for cellular healing

ABSTRACT Studies of the susceptibility of Plasmodium falciparum to the artemisinin family of antimalarial drugs provide a complex picture of partial resistance (tolerance) associated with increased parasite survival in vitro and in vivo. We present an overview of the genetic loci that, in mutant for...

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Veröffentlicht in:	FEMS microbiology reviews 2021-05, Vol.45 (3), p.1
Hauptverfasser:	Sutherland, Colin J, Henrici, Ryan C, Artavanis-Tsakonas, Katerina
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Adaptor proteins Analysis Antimalarials - pharmacology Artemisinin Artemisinins - pharmacology Cytosol Drug Resistance - genetics Drugs Erythrocytes Healing Hemoglobin Hydrolase Malaria Parasites Plasmodium falciparum Plasmodium falciparum - drug effects Plasmodium falciparum - genetics Propellers Proteins Protozoan Proteins - genetics Protozoan Proteins - metabolism Review Schedules Ubiquitin Ubiquitin hydrolase Vector-borne diseases
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