Integrated chromatin and transcriptomic profiling of patient-derived colon cancer organoids identifies personalized drug targets to overcome oxaliplatin resistance

Colorectal cancer is a leading cause of cancer deaths. Most colorectal cancer patients eventually develop chemoresistance to the current standard-of-care therapies. Here, we used patient-derived colorectal cancer organoids to demonstrate that resistant tumor cells undergo significant chromatin chang...

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Veröffentlicht in:	Genes & diseases 2021-03, Vol.8 (2), p.203-214
Hauptverfasser:	Tung, Kuei-Ling, Chen, Kai-Yuan, Negrete, Marcos, Chen, Tianyi, Safi, Alexias, Aljamal, Abed Alhalim, Song, Lingyun, Crawford, Gregory E., Ding, Shengli, Hsu, David S., Shen, Xiling
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry & Molecular Biology Chromatin accessibility Drug screening Full Length Genetics & Heredity Life Sciences & Biomedicine Patient-derived organoids Personalized medicine Science & Technology Target discovery
Online-Zugang:	Volltext
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