NeutrobodyPlex—monitoring SARS-CoV-2 neutralizing immune responses using nanobodies

In light of the COVID-19 pandemic, there is an ongoing need for diagnostic tools to monitor the immune status of large patient cohorts and the effectiveness of vaccination campaigns. Here, we present 11 unique nanobodies (Nbs) specific for the SARS-CoV-2 spike receptor-binding domain (RBD), of which...

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Veröffentlicht in:	EMBO reports 2021-05, Vol.22 (5), p.e52325-n/a
Hauptverfasser:	Wagner, Teresa R, Ostertag, Elena, Kaiser, Philipp D, Gramlich, Marius, Ruetalo, Natalia, Junker, Daniel, Haering, Julia, Traenkle, Bjoern, Becker, Matthias, Dulovic, Alex, Schweizer, Helen, Nueske, Stefan, Scholz, Armin, Zeck, Anne, Schenke-Layland, Katja, Nelde, Annika, Strengert, Monika, Walz, Juliane S, Zocher, Georg, Stehle, Thilo, Schindler, Michael, Schneiderhan-Marra, Nicole, Rothbauer, Ulrich
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE2 Angiotensin Angiotensin-converting enzyme 2 Antibodies Binding COVID-19 Domains EMBO19 EMBO23 EMBO40 Epitope mapping Immune response Immune status Monitoring Multiplexing Nanobodies Neutralization Neutralizing neutralizing antibodies Pandemics Receptors SARS‐CoV‐2 serological assay Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Spikes Structural analysis Vaccination Viral diseases
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