Predominant Expression of Mutant EGFR (EGFRvIII) is Rare in Primary Glioblastomas

EGFR amplification is a frequent genetic alteration in primary (de novo) glioblastomas, and is often associated with structural alterations. Most common is variant III (EGFRvIII), which results from a non‐random 801 bp in‐frame deletion of exons 2 to 7 of the EGFR gene. We assessed amplification and...

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Veröffentlicht in:	Brain pathology (Zurich, Switzerland) Switzerland), 2004-04, Vol.14 (2), p.131-136
Hauptverfasser:	Biernat, Wojciech, Huang, Hervé, Yokoo, Hideaki, Kleihues, Paul, Ohgaki, Hiroko
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Brain Neoplasms - genetics Female Gene Amplification Glioblastoma - genetics Humans Image Processing, Computer-Assisted Immunohistochemistry Male Middle Aged Mutation Receptor, Epidermal Growth Factor - genetics Reverse Transcriptase Polymerase Chain Reaction
Online-Zugang:	Volltext
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