Intraneuronal APP/Aβ Trafficking and Plaque Formation in β-Amyloid Precursor Protein and Presenilin-1 Transgenic Mice

Neuropil deposition of β‐amyloid peptides Aβ40 and Aβ42 is believed to be the key event in the neurodegenerative processes of Alzheimer's disease (AD). Since Aβ seems to carry a transport signal that is required for axonal sorting of its precursor β‐amyloid precursor protein (APP), we studied t...

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Veröffentlicht in:	Brain pathology (Zurich, Switzerland) Switzerland), 2002-07, Vol.12 (3), p.275-286
Hauptverfasser:	Wirths, Oliver, Multhaup, Gerd, Czech, Christian, Feldmann, Nicole, Blanchard, Véronique, Tremp, Günter, Beyreuther, Konrad, Pradier, Laurent, Bayer, Thomas A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Alzheimer Disease - pathology Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - metabolism Animals Antibodies - analysis Blotting, Western Brain - metabolism Brain - pathology Immunohistochemistry Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Transgenic Mutation Neurons - metabolism Neurons - pathology Plaque, Amyloid - pathology Polymerase Chain Reaction Presenilin-1 Protein Transport Surface Plasmon Resonance Time Factors
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